Interaction of Innate lymphoid cells with neurons in brain homeostasis and in Toxoplasma infection-induced neuroinflammation

先天淋巴细胞与神经元在脑稳态和弓形虫感染引起的神经炎症中的相互作用

• 批准号: 320380335
• 负责人: Professorin Dr. Ildikò Rita Dunay
• 金额: --
• 依托单位: Institut für Inflammation und Neurodegeneration
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/320380335?language=en
• 关键词: Interaction; Innate; lymphoid; cells; neurons

The close interaction between the immune and nervous system has long been perceived. It has been lately shown, that tissue-resident innate lymphoid cells (ILCs) in the gut are affected by various neuronal signals regulating tissue homeostasis and inflammation. Recently became evident that ILCs in the central nervous system (CNS) are in close proximity to the blood-brain barrier regulating vascular integrity as well as neuroinflammatory processes, however the profound communication pathways remained undefined. We could currently show that certain ILC subpopulations are present in different compartments of the CNS during steady-state condition and their number is elevated upon neuroinflammation. Besides, we have described the close interaction between immune cells with CNS resident cells upon Toxoplasma infection-induced neuroinflammation resulting in distinct neuronal alterations.In the following experiments, we will further characterize the complex functions of ILC subpopulations and their interaction with neurons in the CNS in health and disease. The obtained results will help to understand the bidirectional communication between the immune system and the CNS in health and disease.

免疫系统和神经系统之间的密切相互作用早已被认识到。最近的研究表明，肠道中的组织驻留先天淋巴细胞（ILC）受到调节组织稳态和炎症的各种神经元信号的影响。近年来发现，中枢神经系统（CNS）中的ILC与调节血管完整性和神经炎症过程的血脑屏障非常接近，但其深层的通讯途径仍不清楚。我们目前可以表明，某些ILC亚群存在于稳态条件下的CNS的不同隔室中，并且它们的数量在神经炎症后升高。此外，我们已经描述了免疫细胞与CNS驻留细胞之间的密切相互作用，在弓形虫感染诱导的神经炎症导致不同的神经元alteration.In以下实验中，我们将进一步表征ILC亚群的复杂功能，以及它们与CNS中的神经元在健康和疾病的相互作用。所获得的结果将有助于理解免疫系统和CNS在健康和疾病中的双向通信。