Direct visualization of conformational dynamics of hemagglutinin and interaction between hemagglutinin and exosomes using high-speed atomic force microscopy.

使用高速原子力显微镜直接可视化血凝素的构象动力学以及血凝素和外泌体之间的相互作用。

• 批准号: 19K23841
• 负责人: Lim Kee Siang
• 金额: $ 1.83万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-08-30 至 2021-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K23841/
• 关键词: Hemagglutinin; Influenza A; HS-AFM; Fusogenic transition; viral fusion protein; Influenz A; Virulence factor; High Speed AFM; Exosome

项目成果

Direct visualization of avian influenza H5N1 hemagglutinin precursor and its conformational changes by high-speed atomic force microscopy.

通过高速原子力显微镜直接观察禽流感 H5N1 血凝素前体及其构象变化。

• 发表时间: 2020
• 作者: Higashijima Yoshiki;Nagai Nao;Yamamoto Masamichi;Kitazawa Taro;Kawamura Yumiko K.;Taguchi Akashi;Nakada Natsuko;Nangaku Masaomi;Furukawa Tetsushi;Aburatani Hiroyuki;Kurihara Hiroki;Wada Youichiro;Kanki Yasuharu;Lim Kee Siang
• 通讯作者: Lim Kee Siang

High-Speed AFM Reveals Molecular Dynamics of Human Influenza A Hemagglutinin and Its Interaction with Exosomes

• DOI: 10.1021/acs.nanolett.0c01755
• 发表时间: 2020-09-09
• 期刊: NANO LETTERS
• 影响因子: 10.8
• 作者: Lim, Keesiang;Kodera, Noriyuki;Wong, Richard W.
• 通讯作者: Wong, Richard W.

Direct visualization of avian influenza H5N1 hemagglutinin precursor and its conformational change by high-speed atomic force microscopy

• DOI: 10.1016/j.bbagen.2019.02.015
• 发表时间: 2020-02-01
• 期刊: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
• 影响因子: 3
• 作者: Lim, Kee Siang;Mohamed, Mahmoud Shaaban;Wong, Richard W.
• 通讯作者: Wong, Richard W.