Unveiling Novel STAT1 Activation Expands its Anti-viral Role into Host Defense Against Bacterial Pathogens

新型 STAT1 激活的揭晓将其抗病毒作用扩展到宿主针对细菌病原体的防御

• 批准号: 19K23864
• 负责人: METWALLY HOZAIFA
• 金额: $ 1.83万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-08-30 至 2021-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K23864/
• 关键词: STAT1; Threonine; Phosphorylation; Cytokines; Infection; Inflammation; phosphorylation; TLR4; cytokines; Thr749; Interferon; Tyr701; threonine749; macrophages; infection

项目成果

The Yin and the Yang of STAT1 Downstream of TLR4 Endocytosis: STAT1 beyond Interferon Signaling

TLR4 内吞作用下游 STAT1 的阴阳：STAT1 超越干扰素信号转导

• DOI: 10.33696/immunology.2.044
• 发表时间: 2020
• 期刊: Journal of Cellular Immunology
• 作者: Metwally Hozaifa;Kishimoto Tadamitsu
• 通讯作者: Kishimoto Tadamitsu

STAT1 displays functionally distinct phosphorylation upon LPS stimulation.

STAT1 在 LPS 刺激下表现出功能上不同的磷酸化。

• 发表时间: 2020
• 作者: Adachi K;Asada Y;Hirakata T;Onoue M;Iwamoto S;Kasuga T;Matsuda A.;Hozaifa Metwally and Tadamitsu Kishimoto
• 通讯作者: Hozaifa Metwally and Tadamitsu Kishimoto

Distinct Phosphorylation of STAT1 Confers Distinct DNA Binding and Gene-regulatory Properties

STAT1 的独特磷酸化赋予独特的 DNA 结合和基因调控特性

• DOI: 10.33696/signaling.1.012
• 发表时间: 2020
• 期刊: Journal of Cellular Signaling
• 作者: Metwally Hozaifa;Kishimoto Tadamitsu
• 通讯作者: Kishimoto Tadamitsu

Noncanonical STAT1 phosphorylation expands its transcriptional activity into promoting LPS-induced IL-6 and IL-12p40 production

• DOI: 10.1126/scisignal.aay0574
• 发表时间: 2020-03-24
• 期刊: SCIENCE SIGNALING
• 影响因子: 7.3
• 作者: Metwally, Hozaifa;Tanaka, Toshio;Kishimoto, Tadamitsu
• 通讯作者: Kishimoto, Tadamitsu