GRK 2336: Resolution of inflammation – Mediators, signaling and therapeutic options

研究训练组（RTG）的目标是培养炎症解决（ROI）领域的博士生。ROI的基本机制和失调通路的特点是免疫细胞与生物化学多样性介质之间复杂的相互作用。炎症的消退阶段包括从感染和损伤部位清除炎症细胞及其介质，以恢复组织稳态。这个研究课题现在在一个结构化的培训计划中进行，该计划与一个雄心勃勃的、前沿的科学研究计划相结合，在基础科学和生物医学方面都具有前瞻性。希望该项目能够吸引有才华的下一代科学家进入这个新兴的转化科学领域，并牢固地将ROI作为医学院的结构贷款组成部分。与RTG相关的研究的总体假设是基于积极和可诱导过程参与ROI的证据。在RTG中，研究项目研究参与分辨率相关过程的细胞和介质，以及所涉及的信号级联和目标结构，目的是确定与失调的ROI相关的变化。博士生将从法兰克福歌德大学和乔治-施佩尔-豪斯（GSH）的医学院（FB 16）和生物化学、化学和药学院（FB 14）招募到12个研究小组。通过关注1)来自死亡细胞的信号，2)免疫细胞的极化，以及3)屏障功能的恢复，保证了各个研究项目之间的协同和附加值。项目利用原始人体材料、临床前相关动物模型和细胞系统，结合生物化学、分子生物学、药理学和系统生物学方法。RTG的教育计划提供必要的理论和方法培训，以确保有效，及时和成功完成每篇博士论文。这将通过个性化的监督和指导计划，以及与主题相关的研讨会，实践课程和可转移技能讲习班来支持。我们的目的是帮助学生获得个人的科学品格/个性，促进早期的独立性。后一个方面将通过强制性参与组织项目管理会议、团队合作项目、研究数据管理和接受个人组织责任来促进，例如，邀请和陪同演讲嘉宾，以及策划和主持暑期学校的会议。

The goal of the research training group (RTG) is to train PhD students in the field of resolution of inflammation (ROI). Basic mechanisms and dysregulated pathways of ROI are characterized by complex interactions between immune cells and biochemically diverse mediators. The resolution phase of inflammation involves the elimination of inflammatory cells and their mediators from sites of infection and injury to restore tissue homeostasis. This research topic is now addressed in a structured training program that has been combined with an ambitious, cutting edge scientific research programme, that is forward-looking in terms of both basic science and biomedicine. It is hoped that the program will attract talented, next generation scientists towards this emerging field of translational science and to firmly establish the subject of ROI as a structure-lending component at the faculty of medicine. The overarching hypothesis of the research linked to the RTG is based on evidence that active and inducible processes are involved in ROI. Within the RTG, research projects study the cells and mediators involved in resolution-associated processes as well as the signaling cascades and target structures involved - with the aim of identifying alterations linked to dysregulated ROI. PhD students will be recruited to twelve research groups from the Faculties of Medicine (FB 16) and Biochemistry, Chemistry and Pharmacy (FB 14) at the Goethe-University Frankfurt and the Georg-Speyer-Haus (GSH). Synergy and added value between the individual research projects are guaranteed by the focus on 1) signals derived from dying cells, 2) polarization of immune cells, and 3) restoration of barrier function. Projects make use of primary human material, preclinically relevant animal models and cellular systems combined with biochemical, molecular biology, pharmacological and systems biology approaches.The educational program of the RTG provides the necessary theoretical and methodological training to ensure an efficient, timely, and successful completion of each PhD thesis. This will be backed up by an individualized supervision and coaching program, as well as topic-related seminars, practical courses, and transferable skill workshops. It is our intention to help students gain an individual scientific character/personality and promote early independence. The latter aspects will be promoted by obligatory involvement in the organization of project management meetings, teamwork projects, research data management and the acceptance of personal organizational responsibilities e.g., the invitation and accompaniment of guest speakers, as well as planning and chairing session at our summer schools.