Development of Molecular Therapy for Esophageal and Gastric Cancer Based on Cancer Host Linkage Regulation by Analysis of Exosomes and Intestinal Microbiota

通过分析外泌体和肠道微生物群，开发基于癌症宿主连锁调节的食管癌和胃癌分子治疗

• 批准号: 20H03749
• 负责人: Matsubara Hisahiro
• 金额: $ 11.4万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2020
• 资助国家: 日本
• 起止时间: 2020-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20H03749/
• 关键词: エクソソーム; 腸内細菌叢; 食道癌; 胃癌; バイオマーカー; 分子治療; 書道癌

项目成果

Association of microbiota with cancer treatment

微生物群与癌症治疗的关联

• DOI: 10.1007/s10147-023-02302-4
• 发表时间: 2023
• 期刊: International Journal of Clinical Oncology
• 影响因子: 3.3
• 作者: Ishikawa K;Sugimoto S;Oda M;Fujii M;Toshimitsu K;Sawada K;Shimokawa M;Saito M;Kawasaki K;Ishii R;Taniguchi K;Sato T.;Yoshimura Kiyoshi
• 通讯作者: Yoshimura Kiyoshi

ω3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor α

• DOI: 10.1096/fj.202001687r
• 发表时间: 2021-04-01
• 期刊: FASEB JOURNAL
• 影响因子: 4.8
• 作者: Saika, Azusa;Nagatake, Takahiro;Kunisawa, Jun
• 通讯作者: Kunisawa, Jun

XCL1 expression correlates with CD8-positive T cells infiltration and PD-L1 expression in squamous cell carcinoma arising from mature cystic teratoma of the ovary

• DOI: 10.1038/s41388-020-1237-0
• 发表时间: 2020-03-02
• 期刊: ONCOGENE
• 影响因子: 8
• 作者: Tamura, Ryo;Yoshihara, Kosuke;Enomoto, Takayuki
• 通讯作者: Enomoto, Takayuki

Soluble PD-L1 Concentration Is Proportional to the Expression of PD-L1 in Tissue and Is Associated with a Poor Prognosis in Esophageal Squamous Cell Carcinoma.

• DOI: 10.1159/000518740
• 发表时间: 2022-01-01
• 期刊: Oncology
• 影响因子: 3.5
• 作者: Shiraishi, Tadashi;Toyozumi, Takeshi;Matsubara, Hisahiro
• 通讯作者: Matsubara, Hisahiro

食道がんの最新知見

食管癌的最新发现

• 发表时间: 2021
• 作者: Ito T;Sakai A;Maruyama M;Miyagawa Y;Okada T;Fukayama H;Suzuki H.;岡田尚巳;松原 久裕
• 通讯作者: 松原 久裕