Externally Triggered Nanomachine for Breast Cancer Theranostics

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A photo-oxidative nanozyme for cancer theranostics was demonstrated at normoxic conditions on breast cancer B16-F10 mouse melanoma with high metastatic potential. The experimental data revealed that the metastatic migration might be controlled by nanozyme and applied near-infrared energy dosage. The biocompatibility of the nanozyme was proved on ATPase activity of intact mitochondria and sub-mitochondrial particles, on diamine oxidase activity of liver and kidney fractions in dark mode, as well as on non-illuminated adenocarcinoma human alveolar basal epithelial cells (A549) and human liver cancer cells (HepG2). The effective therapeutic amount (~50 mg/l) was found to be 10-fold lower than the threshold dose (> 500 mg/l) and it did not influenced the signal pathways of the healthy cells.