SFB 1315: Mechanisms and disturbances in memory consolidation: From synapses to systems

这个协作研究中心（CRC）专注于系统内存整合。也就是说，它不仅研究大脑中与记忆相关的结构如何保留长期信息，还研究大脑如何将这些信息转化为与特定记忆相对应的事实、知识和技能。这个主题可以被视为大脑研究的核心问题之一，也是CRC的理想主题，因为它很难由单个实验室单独解决。第一轮的研究非常成功，取得了许多突破，发表了许多论文。总的来说，该联盟提供了关于海马中产生的最终导致皮层记忆的信号，这些信号到达哪里以及它们的作用是什么的见解。这种基础研究已经改变了我们看待记忆巩固的方式。对于我们的第二个资助期申请，我们已经确定了一些在第一轮申请中重点关注的主题。这些研究包括海马体中产生的与记忆相关的活动的性质，从内侧颞叶到新皮层的信息传递，编码记忆的细胞集合的细化（印痕），睡眠的作用，记忆回路，以及大脑刺激如何影响记忆。我们引入了三个新的科学项目来加强成功的主题，并利用了10个新的项目负责人，他们要么已经抵达柏林，要么与CRC的目标保持一致。我们将增加研究范围，包括与记忆相关的分子事件和记忆巩固的大规模动态。为此，我们引进了在局部蛋白质合成的分子基础和动物行为方面具有专业知识的新pi，以及在大规模系统中工作的临床，实验和理论领域的pi。在第二轮中，我们还将引入由PI Ritter领导的一个强大的基础设施项目，该项目将进一步发展这些可重复研究的战略，并将该联盟整合到德国和欧洲正在进行的数据管理计划中。总之，CRC 1315最大限度地利用了柏林现有的神经科学界调查记忆。

This Collaborative Research Center (CRC) focuses on systems memory consolidation. That is, it investigates not just how memory-related structures in the brain retain long-term information, but how the brain transforms this information into facts, knowledge and skills that correspond to specific memories. This topic can be seen as one of the central issues in brain research and it is also an ideal topic for a CRC because it is difficult to tackle by individual laboratories working alone. The first round of the CRC was very successful with many breakthroughs and publications. Overall, the consortium provided insight into what signals originate in the hippocampus that eventually lead to memories in the cortex, where these signals arrive and what their action is. This kind of foundational research has already changed the way we look at memory consolidation.For our second funding period application, we have identified a number of themes that were brought into focus during the first round. These include the nature of memory-related activity generated in the hippocampus, the transfer of information from the medial temporal lobe to neocortex, the refinement of ensembles of cells for encoding memories (engrams), the role of sleep, memory loops, and how brain stimulation influences memory. We introduce three new scientific projects to enhance the successful themes and take advantage of ten new PIs who have either arrived in Berlin or become aligned to the goals of the CRC. We will increase the range of investigations to include both molecular events related to memory and large-scale dynamics of memory consolidation. To do this, we have brought in new PIs with expertise in the molecular underpinnings of local protein synthesis and in animal behavior, as well as PIs in the clinical, experimental and theoretical domains working on large-scale systems. For the second round, we will also introduce a robust infrastructure project led by PI Ritter that will further develop these strategies for reproducible research and integrate the consortium into ongoing data management initiatives around Germany and Europe.In summary, the CRC 1315 takes maximum advantage of the existing neuroscientific community investigating memory in Berlin.