Establishment of a virtual clinical trial system considering variations in factors governing drug tissue distribution, efficacy, and side effects.

考虑药物组织分布、疗效和副作用因素变化的虚拟临床试验系统的建立。

• 批准号: 19H03392
• 负责人: Sugiyama Yuichi
• 金额: $ 10.57万
• 依托单位: Josai International University (2021-2022)Institute of Physical and Chemical Research (2019-2020)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19H03392/
• 关键词: 生理学的薬物速度論（PBPKモデル）; 薬物間相互作用 （DDI）; In vitroからin vivoへの予測; 薬物間相互作用; 生理学的薬物速度論モデル（PBPK）; 内在性バイオマーカー; 薬物動態; 個人間変動; モデリング＆シミュレーション; 仮想臨床試験; トランスポータ; アルブミン介在性輸送

项目成果

Expanded Physiologically-Based Pharmacokinetic Model of Rifampicin for Predicting Interactions With Drugs and an Endogenous Biomarker via Complex Mechanisms Including Organic Anion Transporting Polypeptide 1B Induction

• DOI: 10.1002/psp4.12457
• 发表时间: 2019-11-01
• 期刊: CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
• 影响因子: 3.5
• 作者: Asaumi, Ryuta;Menzel, Karsten;Sugiyama, Yuichi
• 通讯作者: Sugiyama, Yuichi

Role of transporter sciences in new drug discovery and development.

转运蛋白科学在新药发现和开发中的作用。

• 发表时间: 2021
• 作者: Kim Soo-Jin;Lee Kyeong-Ryoon;Miyauchi Seiji;Sugiyama Yuichi;Yuichi Sugiyama;Yuichi Sugiyama;Yuichi Sugiyama;Yuichi Sugiyama;Yuichi Sugiyama
• 通讯作者: Yuichi Sugiyama

Prediction of the effects of transporter mediated drug-drug interaction and pharmacogenomics on pharmacokinetics (PK) /pharmacodynamics (PD) / toxicodynamics (TD).

预测转运蛋白介导的药物相互作用和药物基因组学对药代动力学（PK）/药效学（PD）/毒效动力学（TD）的影响。

• 发表时间: 2019
• 作者: Kim Soo-Jin;Lee Kyeong-Ryoon;Miyauchi Seiji;Sugiyama Yuichi;Yuichi Sugiyama;Yuichi Sugiyama;Yuichi Sugiyama;Yuichi Sugiyama;Yuichi Sugiyama;Yuichi Sugiyama;Yuichi Sugiyama
• 通讯作者: Yuichi Sugiyama

Physiologically-Based Pharmacokinetic Modeling Analysis for Quantitative Prediction of Renal Transporter-Mediated Interactions Between Metformin and Cimetidine

• DOI: 10.1002/psp4.12398
• 发表时间: 2019-06-01
• 期刊: CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
• 影响因子: 3.5
• 作者: Nishiyama, Kotaro;Toshimoto, Kota;Sugiyama, Yuichi
• 通讯作者: Sugiyama, Yuichi

Use of Extended Clearance Concept and PBPK Modeling in New Drug Discovery and Development: Predicting Target Tissue Exposure from In Vitro to In Vivo.

延长清除概念和 PBPK 模型在新药发现和开发中的应用：预测从体外到体内的靶组织暴露。

• 发表时间: 2021
• 作者: Kim Soo-Jin;Lee Kyeong-Ryoon;Miyauchi Seiji;Sugiyama Yuichi;Yuichi Sugiyama;Yuichi Sugiyama;Yuichi Sugiyama;Yuichi Sugiyama
• 通讯作者: Yuichi Sugiyama