Establishment of strategy for the treatment of lung cancer harboring rare mutations

罕见突变肺癌治疗策略的建立

• 批准号: 19H03671
• 负责人: Soejima Kenzo
• 金额: $ 11.15万
• 依托单位: University of Yamanashi (2021-2022)Keio University (2019-2020)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19H03671/
• 关键词: 肺癌; 稀な遺伝子変異; EGFR遺伝子変異; 医師主導治験; オルガノイド; KRAS遺伝子変異; multiomics解析; 臨床試験; 薬剤感受性; 稀な遺伝子編; 臨床研究; EGFR exon 20挿入遺伝子; 稀な遺伝子異常; スーパーコンピューター

项目成果

Trends of concerns from diagnosis in patients with advanced lung cancer and their family caregivers: A 2-year longitudinal study.

• DOI: 10.1177/02692163211001721
• 发表时间: 2021-05
• 期刊: Palliative medicine
• 影响因子: 4.4
• 作者: Sato T;Fujisawa D;Arai D;Nakachi I;Takeuchi M;Nukaga S;Kobayashi K;Ikemura S;Terai H;Yasuda H;Kawada I;Sato Y;Satomi R;Takahashi S;Hashiguchi MH;Nakamura M;Oyamada Y;Terashima T;Sayama K;Saito F;Sakamaki F;Inoue T;Naoki K;Fukunaga K;Soejima K
• 通讯作者: Soejima K

Real-world clinical practice for advanced non-small-cell lung cancer in the very elderly: A retrospective multicenter analysis

• DOI: 10.1016/j.cllc.2022.05.003
• 发表时间: 2022-09-01
• 期刊: CLINICAL LUNG CANCER
• 影响因子: 3.6
• 作者: Fukushima, Takahiro;Oyamada, Yoshitaka;Soejima, Kenzo
• 通讯作者: Soejima, Kenzo

Molecular dynamics simulation-guided drug sensitivity prediction for lung cancer with rare EGFR mutations

• DOI: 10.1073/pnas.1819430116
• 发表时间: 2019-05-14
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Ikemura, Shinnosuke;Yasuda, Hiroyuki;Soejima, Kenzo
• 通讯作者: Soejima, Kenzo

A phase II trial of induction of erlotinib followed by cytotoxic chemotherapy for EGFR mutation-positive non-squamous non-small cell lung cancer patients.

对 EGFR 突变阳性非鳞状非小细胞肺癌患者进行厄洛替尼诱导后进行细胞毒性化疗的 II 期试验。

• DOI: 10.1007/s00280-019-03934-y
• 发表时间: 2019
• 期刊: Cancer Chemother Pharmacol
• 作者: Tani T;Naoki K;Yasuda H;Arai D;Ishioka K;Ohgino K;Yoda S;Nakayama S;Satomi R;Terai H;Ikemura S;Sato T;Soejima K.
• 通讯作者: Soejima K.

Comparative performance analysis of interventional devices for the treatment of ischemic disease in below-the-knee lesions: a systematic review and meta-analysis.

• DOI: 10.1007/s12928-021-00758-7
• 发表时间: 2022-01
• 期刊: Cardiovascular intervention and therapeutics
• 影响因子: 3.2
• 作者: Matsuoka EK;Hasebe T;Ishii R;Miyazaki N;Soejima K;Iwasaki K
• 通讯作者: Iwasaki K