Comprehensive genomic and transcriptome analyses to clarify molecular mechanisms contributing to chemoresistance in gynecologic cancer

全面的基因组和转录组分析，以阐明导致妇科癌症化疗耐药的分子机制

• 批准号: 19H03795
• 负责人: YAEGASHI Nobuo
• 金额: $ 11.15万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19H03795/
• 关键词: 卵巣癌; 薬剤耐性; バイオマーカー; オミックス; メタボロミクス; 婦人科がん; がんゲノム解析; メタボローム; 循環腫瘍DNA

项目成果

Liquid biopsy with droplet digital PCR targeted to specific mutations in plasma cell-free tumor DNA can detect ovarian cancer recurrence earlier than CA125.

• DOI: 10.1016/j.gore.2021.100847
• 发表时间: 2021-11
• 期刊: Gynecologic oncology reports
• 影响因子: 1.2
• 作者: Minato T;Ito S;Li B;Fujimori H;Mochizuki M;Yamaguchi K;Tamai K;Shimada M;Tokunaga H;Shigeta S;Sato I;Shima H;Yamada H;Yaegashi N;Yasuda J
• 通讯作者: Yasuda J

Association between hospital treatment volume and survival of women with gynecologic malignancy in Japan: a JSOG tumor registry-based data extraction study.

• DOI: 10.3802/jgo.2022.33.e3
• 发表时间: 2022-01
• 期刊: Journal of gynecologic oncology
• 影响因子: 3.9
• 作者: Machida H;Matsuo K;Oba K;Aoki D;Enomoto T;Okamoto A;Katabuchi H;Nagase S;Mandai M;Yaegashi N;Yamagami W;Mikami M
• 通讯作者: Mikami M

The trend and outcome of postsurgical therapy for high-risk early-stage cervical cancer with lymph node metastasis in Japan: a report from the Japan Society of Gynecologic Oncology (JSGO) guidelines evaluation committee.

• DOI: 10.3802/jgo.2021.32.e44
• 发表时间: 2021-05
• 期刊: Journal of gynecologic oncology
• 影响因子: 3.9
• 作者: Ikeda M;Shida M;Shigeta S;Nagase S;Takahashi F;Yamagami W;Katabuchi H;Yaegashi N;Aoki D;Mikami M
• 通讯作者: Mikami M

The efficacy and safety profile of 2-weekly dosing of bevacizumab-containing chemotherapy for platinum-resistant recurrent ovarian cancer.

• DOI: 10.1007/s10147-021-01996-8
• 发表时间: 2021-11
• 期刊: International journal of clinical oncology
• 影响因子: 3.3
• 作者: Sekine M;Enomoto T;Watanabe Y;Katabuchi H;Yaegashi N;Aoki D
• 通讯作者: Aoki D

Human papillomavirus vaccine effectiveness by age at first vaccination among Japanese women.

• DOI: 10.1111/cas.15270
• 发表时间: 2022-04
• 期刊: Cancer science
• 影响因子: 5.7
• 作者: Onuki M;Yamamoto K;Yahata H;Kanao H;Yokota H;Kato H;Shimamoto K;Takehara K;Kamiura S;Tsuda N;Takei Y;Shigeta S;Matsumura N;Yoshida H;Motohara T;Watari H;Nakamura K;Ueda A;Tasaka N;Ishikawa M;Hirashima Y;Kudaka W;Taguchi A;Iwata T;Takahashi F;Kukimoto I;Yoshikawa H;Yaegashi N;Matsumoto K;MINT Study Group
• 通讯作者: MINT Study Group