Functional relevance of the extracellular matrix molecules Periostin and Tenascin C in liver damage and regeneration (A18#)

细胞外基质分子 Periostin 和 Tenascin C 在肝损伤和再生中的功能相关性 (A18

• 批准号: 333317989
• 金额: --
• 依托单位: Institut für Pathologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/333317989?language=en
• 关键词: Functional; relevance; extracellular; matrix; molecules

A severe liver damage is associated with a strong fibrotic reaction. Hereby, hepatic stellate cells are activated and secret various extracellular matrix proteins, such as Periostin and Tenascin C. These proteins generate a specific microenvironmental niche for hepatic progenitor cells and probably influence the activation and expansion of the hepatic progenitor cells as well as their differentiation potential towards hepatocytes. Accordingly, the process of liver injury and regeneration will be addressed in Periostin and Tenascin C transgenic knockout mouse models and analyzed in detail. Moreover, the investigation of human paraffin-embedded tissue samples of chronic liver diseases should clarify whether the expression of Periostin and Tenascin C shows a correlation with pathophysiological parameters.

严重的肝损伤与强烈的纤维化反应有关。因此，肝星状细胞被激活并分泌各种细胞外基质蛋白，如Periostin和Tenascin c。这些蛋白为肝祖细胞产生特定的微环境生态位，并可能影响肝祖细胞的激活和扩增以及向肝细胞的分化潜力。因此，我们将在Periostin和Tenascin C转基因敲除小鼠模型中研究肝损伤和再生的过程，并对其进行详细分析。此外，对慢性肝病人石蜡包埋组织样本的研究应阐明Periostin和Tenascin C的表达是否与病理生理参数相关。