Endocannabinoid Signaling in the Hypothalamic Arcuate Nucleus: Identification of Novel Players and Mechanisms Controlling Energy Homeostasis (A07*+)

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In the hypothalamic arcuate nucleus (ARC), AgRP and NPY co-expressing neurons rapidly promote food intake and decrease energy expenditure, while POMC neurons drive gradual onset of satiety and increase energy expenditure. Activation of the cannabinoid type 1 receptor (CB1) by exogenous cannabinoids, such as THC, provokes a robust feeding response, despite the respective individual resides in a state of satiety. This project addresses two major questions: (1) Do local endocannabinoids affect POMC and AgRP/NPY neurons in order to maintain energy homeostasis under physiological conditions? (2) Is chronically imbalanced endocannabinoid signaling in the arcuate nucleus relevant for onset and maintenance of metabolic disorders?