Endocannabinoid Signaling in the Hypothalamic Arcuate Nucleus: Identification of Novel Players and Mechanisms Controlling Energy Homeostasis (A07*+)

下丘脑弓状核中的内源性大麻素信号传导：新参与者的识别和控制能量稳态的机制（A07*）

• 批准号: 338335938
• 金额: --
• 依托单位: Lehrstuhl für Anatomie und Zellbiologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/338335938?language=en
• 关键词: Endocannabinoid; Signaling; Hypothalamic; Arcuate; Nucleus

In the hypothalamic arcuate nucleus (ARC), AgRP and NPY co-expressing neurons rapidly promote food intake and decrease energy expenditure, while POMC neurons drive gradual onset of satiety and increase energy expenditure. Activation of the cannabinoid type 1 receptor (CB1) by exogenous cannabinoids, such as THC, provokes a robust feeding response, despite the respective individual resides in a state of satiety. This project addresses two major questions: (1) Do local endocannabinoids affect POMC and AgRP/NPY neurons in order to maintain energy homeostasis under physiological conditions? (2) Is chronically imbalanced endocannabinoid signaling in the arcuate nucleus relevant for onset and maintenance of metabolic disorders?

在下丘脑弓状核（ARC）中，AgRP和NPY共表达神经元快速促进食物摄入并减少能量消耗，而POMC神经元驱动饱腹感的逐渐发作并增加能量消耗。大麻素1型受体（CB 1）被外源性大麻素（如THC）激活引起强烈的进食反应，尽管相应的个体处于饱腹状态。本项目解决了两个主要问题：（1）局部内源性大麻素是否影响POMC和AgRP/NPY神经元，以维持生理条件下的能量稳态？(2)弓状核内内源性大麻素信号的长期不平衡是否与代谢紊乱的发生和维持有关？