The Role of DNA damage and Repair in Skin Aging (B15*)

我们将描述DNA损伤在皮肤老化中的作用，使用独特的小鼠突变体携带DNA修复系统的缺陷，显示加速老化的特征。将使用转基因小鼠模型剖析系统和组织特异性因素、干细胞、应激诱导的终末分化、细胞死亡和细胞衰老的贡献。由于我们已经发现了一种饮食限制，可以显著延长寿命并改善小鼠模型的健康状况，我们将进一步研究预防，延迟甚至部分逆转皮肤老化的干预措施。

We will characterize the role of DNA damage in skin aging, using unique mouse mutants carrying defects in DNA repair systems, displaying features of accelerated aging. The contribution of systemic and tissue-specific factors, stem cells, stress-induced terminal differentiation, cell death and cellular senescence will be dissected using transgenic mouse models. Since we have uncovered a dietary restriction that spectacularly extends life span and improves health of the mouse models we will further investigate interventions which prevent, delay or even partly revert skin aging.