Comprehensive and unbiased analysis of the human SMC5/6 complex: Taking advantage of auxin-inducible degron system

对人类 SMC5/6 复合物进行全面、公正的分析：利用生长素诱导降解决定子系统

• 批准号: 19K06495
• 负责人: NATSUME Toyoaki
• 金额: $ 2.75万
• 依托单位: Tokyo Metropolitan Institute of Medical Science (2021-2022)National Institute of Genetics (2019-2020)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K06495/
• 关键词: SMC5/6; オーキシンデグロン法; 染色体分配; 核内ボディ; 転写; DNA超らせん構造; ヘテロクロマチン; セントロメア; リボソームDNA; DNAの絡まり; 染色体; ヒト細胞

项目成果

Inducible Degradation of the Human SMC5/6 Complex Reveals an Essential Role Only during Interphase

• DOI: 10.1016/j.celrep.2020.107533
• 发表时间: 2020-04-21
• 期刊: CELL REPORTS
• 影响因子: 8.8
• 作者: Venegas, Andres Bueno;Natsume, Toyoaki;Hickson, Ian D.
• 通讯作者: Hickson, Ian D.

Human SMC5/6 and DNA topological stress during chromosome transactions

染色体交易过程中的人类 SMC5/6 和 DNA 拓扑应力

• 发表时间: 2019
• 作者: Yesbolatova A;Natsume T;Hayashi K;Kanemaki MT;夏目 豊彰;夏目 豊彰;Toyoaki Natsume
• 通讯作者: Toyoaki Natsume

Generation of conditional auxin-inducible degron (AID) cells and tight control of degron-fused proteins using the degradation inhibitor auxinole

• DOI: 10.1016/j.ymeth.2019.04.010
• 发表时间: 2019-07-01
• 期刊: METHODS
• 影响因子: 4.8
• 作者: Yesbolatova, Aisha;Natsume, Toyoaki;Kanemaki, Masato T.
• 通讯作者: Kanemaki, Masato T.

Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy.

• DOI: 10.1038/s41467-022-34349-8
• 发表时间: 2022-11-04
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Grange, Laura J.;Reynolds, John J.;Ullah, Farid;Isidor, Bertrand;Shearer, Robert F.;Latypova, Xenia;Baxley, Ryan M.;Oliver, Antony W.;Ganesh, Anil;Cooke, Sophie L.;Jhujh, Satpal S.;McNee, Gavin S.;Hollingworth, Robert;Higgs, Martin R.;Natsume, Toyoaki;Khan, Tahir;Martos-Moreno, Gabriel A.;Chupp, Sharon;Mathew, Christopher G.;Parry, David;Simpson, Michael A.;Nahavandi, Nahid;Yuksel, Zafer;Drasdo, Mojgan;Kron, Anja;Vogt, Petra;Jonasson, Annemarie;Seth, Saad Ahmed;Gonzaga-Jauregui, Claudia;Brigatti, Karlla W.;Stegmann, Alexander P. A.;Kanemaki, Masato;Josifova, Dragana;Uchiyama, Yuri;Oh, Yukiko;Morimoto, Akira;Osaka, Hitoshi;Ammous, Zineb;Argente, Jesus;Matsumoto, Naomichi;Stumpel, Constance T. R. M.;Taylor, Alexander M. R.;Jackson, Andrew P.;Bielinsky, Anja-Katrin;Mailand, Niels;Le Caignec, Cedric;Davis, Erica E.;Stewart, Grant S.
• 通讯作者: Stewart, Grant S.

University of Copenhagen(デンマーク)

哥本哈根大学（丹麦）