The elucidation of the predictive of psychological changes by chemotherapy mediated the serotonin-kynurenine pathway

阐明化疗介导的血清素-犬尿氨酸途径对心理变化的预测

• 批准号: 19K07192
• 负责人: KITAMURA YOSHIHISA
• 金额: $ 2.75万
• 依托单位: Shujitsu University (2020-2021)Okayama University (2019)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K07192/
• 关键词: 抗がん剤; 不安; AC療法; 神経新生; セロトニン; キヌレニン; セロトニン1A受容体作用薬; ドキソルビシン; シクロホスファミド; 化学療法; セロトニン神経系; キヌレニン経路; セロトニン2A受容体; セロトニン1A受容体; 5-HT2A受容体; 5-HT1A受容体; 精神機能; ストレス脆弱性

项目成果

Involvement of 5-HT1A receptor in the anxiety-like behavior induced by doxorubicin and cyclophosphamide combination treatment in rats.

5-HT1A 受体参与多柔比星和环磷酰胺联合治疗诱导的大鼠焦虑样行为。

• 发表时间: 2020
• 作者: Yoshihisa Kitamura;Soichiro Ushio;Yudai Wada;Toshiaki Sendo
• 通讯作者: Toshiaki Sendo

Effects of serotonin1A receptor agonist on doxorubicin and cyclophosphamide-induced anxiety-like behavior in rats

5-羟色胺1A受体激动剂对阿霉素和环磷酰胺诱导的大鼠焦虑样行为的影响

• 发表时间: 2019
• 作者: Yoshihisa Kitamura;Yuka Nakamura;Yusuke Sumiyoshi;Nanami Naito;Yudai Wada;Ikuko Miyazaki;Masato Asanuma;Toshiaki Sendo
• 通讯作者: Toshiaki Sendo

Influence of 5-HT2A receptor function on anxiety-like behavior induced by combination treatment with doxorubicin and cyclophosphamide in rats

5-HT2A受体功能对阿霉素与环磷酰胺联合治疗大鼠焦虑样行为的影响

• DOI: 10.1007/s00213-021-05979-5
• 发表时间: 2021
• 期刊: Psychopharmacology
• 影响因子: 3.4
• 作者: Tabuchi H;Kitamura Y;Ushio S;Kan S;Wada Y;Sumiyoshi Y;Izushi Y;Miyazaki I;Asanuma M;Sendo T.
• 通讯作者: Sendo T.

N-Acetylcysteine Attenuates the Anxiety-Like Behavior and Spatial Cognition Impairment Induced by Doxorubicin and Cyclophosphamide Combination Treatment in Rats

• DOI: 10.1159/000512117
• 发表时间: 2020-12-22
• 期刊: PHARMACOLOGY
• 影响因子: 3.1
• 作者: Kitamura, Yoshihisa;Ushio, Soichiro;Sendo, Toshiaki
• 通讯作者: Sendo, Toshiaki