Development of novel neuroprotective oxicam derivatives for the treatment of Parkinson's disease

开发用于治疗帕金森病的新型神经保护性昔康衍生物

• 批准号: 19K07186
• 负责人: Tasaki Yoshikazu
• 金额: $ 2.83万
• 依托单位: Asahikawa Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K07186/
• 关键词: パーキンソン病進行抑制薬; meloxicam誘導体の開発; 新規治療薬候補; meloxicam誘導体; Akt; 細胞死抑制; meloxicam; 新規抗パーキンソン病薬; Aｋｔ

项目成果

抗パーキンソン病薬を目指した新規オキシカムA環芳香族複素環アナログの創製

新型抗帕金森病药物昔康A环芳香杂环类似物的研制

• 发表时间: 2021
• 作者: 鶴岡 航太朗;小町 元輝;鈴木 啓太;高橋 恭子;中村 成夫;大江 知之;大久保 知子;眞鍋 貴行;田﨑 嘉一;増野 匡彦
• 通讯作者: 増野 匡彦

パーキンソン病治療薬を目指したオキシカムアナログIY104のADME評価 および類縁体合成

昔康类似物 IY104 治疗帕金森病的 ADME 评价和类似物合成

• 发表时间: 2022
• 作者: 鶴岡 航太朗;高橋 恭子;中村 成夫;熊谷 直哉;増野 匡彦;大久保 知子;眞鍋 貴之;田﨑 嘉一;大江 知之
• 通讯作者: 大江 知之

PCT

• DOI: 10.1007/978-3-540-29676-8_6602
• 发表时间: 2019
• 期刊: Springer Reference Medizin
• 作者: M. Braun‐Falco;Henry J. Mankin;Sharon Wenger;Stephan DiSean Kendall;G. Blobe;Christoph Weber;R. Lorenz;G. Adler;David C. Whitcomb;Dhiraj Yadav;J. Bode;M. Wabitsch;K. Debatin;Pamela Fischer Posovzsky;Akmal Hassan;M. Megahed;Tord M. Lundgren;Markus Pfister;H. Zenner;Rossana Berardi;C. Pierantoni;M. Scartozzi;S. Cascinu;G. Hendy;J. Schwarz;Alexander Storch;J. Schnog;V.E.A. Gerdes;Susanne A. Schneider;Kailash P. Bhatia;A. G. Gittenberger-de Groot;R. Bökenkamp;Marco C. DeRuiter;Alexander K. C. Leung;A. L. Wong;U. Lang;Muammer Seyhan;S. Hofmann;Leena Bruckner-Tuderman;P. Kopp;Douglas Forrest;Emine Dibek Misirlioğlu;Nursel Alpan;M. Oette;Massimo Imazio;Kavitha M. Chinnaiyan;L. Mehta;Mushtaq A. Bhat;Javeed I. A. Bhat;G. Stöber;André Reis;J. Rémi;S. Noachtar;K. Jurkat-Rott;Frank Lehmann-Horn;Marinella Holzhausen;N. Vergnolle;Martin Schillinger;H. Gdynia;A. Ludolph;T. Namdar;C. Eisenberger;W. Knoefel;P. Ginés;M. Guevara;A. Cuesta-Muñoz;H. Eijer;Markus Böhm;T. A. Luger;F. Güttler;Per Guldberg;R. Koch;K. Moseley;Graeme Eisenhofer;Karel Pacak;James V. Leonard;J. Jaeken;Michael A. Becker;Ulrich Stephani;Kendall S. Frazier;Reginald S. Sauve;Verena Matejas;Martin Zenker;W. Robson;S. Beissert;Tom Y. Woo;H. T. Cate;Richard W. Light;Patrícia T. Bozza;J. Salluh;Michael A. Jantz;Sergio L Vargas;Radoslav Tomić;Jesse Roman;A. Mobeireek;M. Khalid;Harrys A. Torres;R. Chemaly;A. Dispenzieri;Sabine Krause;Hanns Lochmüller;J. Weihrauch;Thomas Krieg;Wolfgang Kühn;Gerd Walz;Georg H. Merker;R. Kubitz;Dieter Häussinger;G. Musco;G. Stoll;K. Toyka;E. Pischik;Raili Kauppinen;J. Frank;T. Schwarz;Manish Thapar;H. Bonkovsky;J. Wagner;A. Smith;M. Mela;U. Thalheimer;D. Samonakis;A. Burroughs;Yogesh Shastri;J. Stein;R. Segman;A. Shalev;Giris Jacob;David Robertson;K. Lampinen;K. Kublickiene;Risto Kaaja;R. Lenarczyk;Oskar Kowalski;Z. Kalarus;D. Wichterle;Jamie Maguire;Istvan Mody;K. Janssens;Filip Vanhoenacker;W. Van Hul;K. Geboes;G. Van Assche;J. Berden;T. V. van Kuppevelt;A. Rops;C. M. Ambros-Rudolph;V. Lamounier-Zepter;Christie P. Thomas;Christian Bender Koch;L. Weinstein;C. Silve;Jouni Uitto;Qiujie Jiang;Orhan Yıldız;Uner Kayabas;R. Hegele;Jean-Nicolas Tournier;Ahmet Mesrur Halefoğlu;M. Hutson;M. Kirby;F. Okada;Y. Ando;A. Ono;H. Mori;Timothy M. Moore;M. Townsley;M. Krauth;I. Pabinger;M. Ballmann;Terence K. Trow;Vallerie V. McLaughlin;Atteyet-Alla Fetouh Yassin;A. Uebing;Michael A. Gatzoulis;Helena M. Gardiner;Lucia K. Ma;Patrick T. S. Ma;Lourdes Prieto;Larry Latson;N. R. Keller;L. Fairbanks;H. Simmonds;M. Brunner;C. Zouboulis;Vincent Everts;M. Helfrich;Peter von den Driesch;R. Bitsch;À. García-Cazorla;J. Saudubray