Functional evaluation of the candidate proteins of hepatitis E virus receptor and identification of host factors involved in the permissibility of infection

戊型肝炎病毒受体候选蛋白的功能评价及感染许可性宿主因素的鉴定

• 批准号: 19K07579
• 负责人: Nagashima Shigeo
• 金额: $ 2.75万
• 依托单位: Jichi Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K07579/
• 关键词: E型肝炎ウイルス; 受容体; 感染許容性; 細胞内侵入; 細胞間伝播; 粒子形成; 許容性; 感染感受性; 感染初期過程; エクソソーム

项目成果

Functional analysis of a highly conserved YXXΦ motif in the ORF2 protein of hepatitis E virus

戊型肝炎病毒ORF2蛋白中高度保守的YXXΦ基序的功能分析

• 发表时间: 2021
• 作者: Shigeo Nagashima;Putu Prathiwi Primadharsini;Masaharu Takahashi;Hiroaki Okamoto;Kazumoto Murata
• 通讯作者: Kazumoto Murata

The tight junction protein ZO-1 is necessary for growth of hepatitis E virus in cultured cells

紧密连接蛋白 ZO-1 对于戊型肝炎病毒在培养细胞中的生长是必需的

• 发表时间: 2019
• 作者: Shigeo Nagashima;Putu Prathiwi Primadharsini;Tominari Kobayashi;Masaharu Takahashi;Hiroaki Okamoto
• 通讯作者: Hiroaki Okamoto

A Nationwide Survey of Hepatitis E Virus Infection and Chronic Hepatitis in Heart and Kidney Transplant Recipients in Japan

• DOI: 10.1097/tp.0000000000002801
• 发表时间: 2020-02-01
• 期刊: TRANSPLANTATION
• 影响因子: 6.2
• 作者: Owada, Yohei;Oshiro, Yukio;Ohkohchi, Nobuhiro
• 通讯作者: Ohkohchi, Nobuhiro

Antiviral candidates against the hepatitis E virus (HEV) and their combinations inhibit HEV growth in in vitro

• DOI: 10.1016/j.antiviral.2019.104570
• 发表时间: 2019-10-01
• 期刊: ANTIVIRAL RESEARCH
• 影响因子: 7.6
• 作者: Nishiyama, Takashi;Kobayashi, Tominari;Okamoto, Hiroaki
• 通讯作者: Okamoto, Hiroaki

The spontaneous clearance of hepatitis E virus (HEV) and emergence of HEV antibodies in a transfusion-transmitted chronic hepatitis E case after completion of chemotherapy for acute myeloid leukemia

急性髓性白血病化疗结束后输血传播的慢性戊型肝炎病例中戊型肝炎病毒（HEV）的自发清除和HEV抗体的出现

• DOI: 10.1007/s12328-019-01024-3
• 发表时间: 2020
• 期刊: Clinical Journal of Gastroenterology
• 影响因子: 1
• 作者: Okano H;Nakano T;Ito R;Tanaka A;Hoshi Y;Matsubayashi K;Asakawa H;Nose K;Tsuruga S;Tochio T;Kumazawa H;Isono Y;Tanaka H;Matsusaki S;Sase T;Saito T;Mukai K;Nishimura A;Kawakami K;Nagashima S;et al.
• 通讯作者: et al.