Viral regulation of host RNA degradation and its implication on hepatocarcinogenesis

病毒对宿主RNA降解的调控及其对肝癌发生的影响

• 批准号: 19K07586
• 负责人: Aly Hussein H
• 金额: $ 2.83万
• 依托单位: National Institute of Infectious Diseases
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K07586/
• 关键词: SKIV2L; HBV; RNA degradation; HBx; Viral Life Cycle; RNA Exosome; Ski2; Viral life cycle; Hepatitis B Virus; Virology

项目成果

Kinesin KIF4 is a key regulator for surface localization of NTCP, and HBV/HDV infection

驱动蛋白 KIF4 是 NTCP 表面定位和 HBV/HDV 感染的关键调节因子

• 发表时间: 2021
• 作者: Sameh A. Gad;Masaya Sugiyama;Masataka Tsuge;Kosho Wakae;Kento Fukano;Noriyuki Watanabe;Takanobu Kato;Asako Murayama;Yingfang Li;Ikuo Shoji;Kunitada Shimotohno;Kazuaki Chayama;Masamichi Muramatsu;Takaji Wakita;Tomoyoshi Nozaki;Hussein H. Aly
• 通讯作者: Hussein H. Aly

The IL-1 β induced (MafF) is an important regulator of HBV core promoter activity

IL-1β诱导（MafF）是HBV核心启动子活性的重要调节因子

• 发表时间: 2020
• 作者: Marwa K. Ibrahim;Sameh A. Gad;Koichi Watashi;Li Yingfang;Masaya Sugiyama; Masahiko Ito;Asako Murayama;Tetsuro Suzuki;Takanobu Kato;Kunitada Shimotohno;Masamichi Muramatsu;Takaji Wakita;Hussein H. Aly.
• 通讯作者: Hussein H. Aly.

Kinesin KIF4 is a possible therapeutic host target and key regulator for surface localization of NTCP, and HBV/HDV infection

驱动蛋白 KIF4 是 NTCP 表面定位和 HBV/HDV 感染的可能治疗宿主靶点和关键调节因子

• 发表时间: 2021
• 作者: Sameh A. Gad;Masaya Sugiyama;Masataka Tsuge;Kosho Wakae;Kento Fukano;Noriyuki Watanabe;Takanobu Kato;Asako Murayama;Yingfang Li;Ikuo Shoji;Kunitada Shimotohno;Kazuaki Chayama;Masamichi Muramatsu;Takaji Wakita;Tomoyoshi Nozaki;Hussein H. Aly
• 通讯作者: Hussein H. Aly

The IL-1 β induced (MafF) is an important regulator of HBV core promoter activity.

IL-1β诱导(MafF)是HBV核心启动子活性的重要调节因子。

• 发表时间: 2019
• 作者: 1.Marwa K. Ibrahim;Sameh A. Gad;Koichi Watashi;Li Yingfang;Masaya Sugiyama;Masahiko Ito;Asako Murayama;Tetsuro Suzuki;Takanobu Kato;Kunitada Shimotohno;Masamichi Muramatsu;Takaji Wakita;Hussein H. Aly
• 通讯作者: Hussein H. Aly

Identification of natural compounds extracted from crude drugs as novel inhibitors of hepatitis C virus

从药材中提取的天然化合物作为新型丙型肝炎病毒抑制剂的鉴定

• DOI: 10.1016/j.bbrc.2021.06.022
• 发表时间: 2021
• 期刊: Biochemical and Biophysical Research Communications
• 影响因子: 3.1
• 作者: Xin Zheng;Rui Guo;Qingbo Liu;Kousho Wakae;Noriyuki Watanabe;Kento Fukano;Lusheng Que;Yingfang Li;Hussein H. Aly;Koichi Watashi;Ryosuke Suzuki;Asako Murayama;Takanobu Kato;Hideki Aizaki;Takaji Wakita;Xiaoxiao Huang;Yi Yan;Shao-Jiang Song;Masamichi Muramats
• 通讯作者: Masamichi Muramats