Regulation of cancer specific chromatin and transcriptional network by Hmga2

Hmga2 对癌症特异性染色质和转录网络的调节

• 批准号: 19K08842
• 负责人: Yokomizo Takako
• 金额: $ 2.75万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K08842/
• 关键词: Hmga2; 造血幹細胞; MDS; エピゲノム; 白血病

项目成果

The acidic domain of Hmga2 and the domain’s linker region are critical for driving self-renewal of hematopoietic stem cell

• DOI: 10.1007/s12185-021-03274-9
• 发表时间: 2022-01
• 期刊: International Journal of Hematology
• 影响因子: 2.1
• 作者: Yuqi Sun;Sho Kubota;Mihoko Iimori;Ai Hamashima;H. Murakami;J. Bai;Mariko Morii;Takako Yokomizo-Nakano;Motomi Osato;K. Araki;G. Sashida

Overexpression of Hmga2 activates Igf2bp2 and remodels transcriptional program of Tet2-deficient stem cells in myeloid transformation

• DOI: 10.1038/s41388-020-01629-w
• 发表时间: 2021-01-15
• 期刊: ONCOGENE
• 影响因子: 8
• 作者: Bai, Jie;Yokomizo-Nakano, Takako;Sashida, Goro
• 通讯作者: Sashida, Goro