Development of new therapeutic agents for diabetic complications including periodontal disease

开发治疗牙周病等糖尿病并发症的新型治疗剂

• 批准号: 19K10079
• 负责人: OHASHI Akiko
• 金额: $ 2.83万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K10079/
• 关键词: テトラヒドロビオプテリン; 血管障害; 酸化ストレス; 一酸化窒素合成酵素; TRPチャネル; 浸透圧; 輸送体; 一酸化窒素; 活性酸素

项目成果

Maternal Supplementation of Tetrahydrobiopterin Regulates Differentiation of Fetal Brown Adipose Tissue and Contributes to Offspring Metabolic Health

母体补充四氢生物蝶呤可调节胎儿棕色脂肪组织的分化，有助于后代的代谢健康

• 发表时间: 2020
• 作者: Minamino H;Fujita Y;Goto H;Ohashi A;Furuya F;Isomura N;Takesue K;Li Y;Kawarasaki S;Kawada T;Hasegawa H;Inagaki N.
• 通讯作者: Inagaki N.

Tetrahydrobiopterin Is Required for Brown Adipose Tissue Development and Differentiation

四氢生物蝶呤是棕色脂肪组织发育和分化所必需的

• 发表时间: 2019
• 作者: Minamino H;Fujita Y;Oguri Y;Goto T;Ohashi A;Furuya F;Isomura N;Kawarasaki S;Kawada T;Hasegawa H;Inagaki N
• 通讯作者: Inagaki N

Forced expression of mouse progerin attenuates the osteoblast differentiation interrupting beta-catenin signal pathway in vitro.

小鼠早老蛋白的强制表达会减弱成骨细胞的分化，从而在体外中断β-连环蛋白信号通路。

• DOI: 10.1007/s00441-018-2930-y
• 发表时间: 2019
• 期刊: Cell Tissue Res
• 影响因子: 3.6
• 作者: Tsukune Naoya;Naito Masako;Ohashi Akiko;Ninomiya Tadashi;Sato Shuichi;Takahashi Tomihisa
• 通讯作者: Takahashi Tomihisa

Tetrahydrobiopterin Regulates Developmental Differentiation of Brown Adipose Tissue

四氢生物蝶呤调节棕色脂肪组织的发育分化

• 发表时间: 2019
• 作者: Minamino H;Fujita Y;Oguri Y;Goto T;Ohashi A;Furuya F;Isomura N;Kawarasaki S;Kawada T;Hasegawa H;Inagaki N
• 通讯作者: Inagaki N

CRISPR/Cas9-mediated in vivo gene editing reveals that neuronal 5-HT1A receptors in the dorsal raphe nucleus contribute to body temperature regulation in mice

• DOI: 10.1016/j.brainres.2019.06.009
• 发表时间: 2019-09
• 期刊: Brain Research
• 影响因子: 2.9
• 作者: N. Nishitani;Yu Ohmura;K. Nagayasu;Norihiro Shibui;S. Kaneko;Akiko Ohashi;Takayuki Yoshida;A. Yamanaka;M. Yoshioka