Isoporphyrins

该项目旨在开发异卟啉的化学性质，基于我们最近发现的这些化合物的改进途径。在提案有效期内将处理两个主要问题：荧光异卟啉锌衍生物的研究进展本部分着重于优化异卟啉锌与细胞系统相互作用的光学性质和溶解度。异卟啉配体的配位化学研究进展。本部分对迄今未知的三维元素金属异卟啉的制备、氧化还原化学和金属基反应性进行了研究。

The project aims towards the development of the chemistry of isoporphyrins, based on our recent finding of an improved access of these compounds. Two major issues are to be dealt with during the term of the proposal:1. Development of fluorescent zinc isoporphyrin derivatives This part focusses on optimizing optical properties and solubilities of zinc isoporphyrins for interactions with cellular systems.2. Development of the coordination chemistry of isoporphyrin ligandsIn this part the preparation, redox chemistry and metal based reactivity of hitherto unknown metal isoporphyrins of the 3d elements are investigated.