The development of genome-wide polygenic risk scores for the prediction of cancer risk, and the evaluation of their ability to discriminate cancer risk.

开发用于预测癌症风险的全基因组多基因风险评分，并评估其区分癌症风险的能力。

• 批准号: 19K10655
• 负责人: Yamaji Taiki
• 金额: $ 2.75万
• 依托单位: National Cancer Center Japan
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K10655/
• 关键词: がん罹患リスク予測モデル; 多因子遺伝的リスクスコア; Polygenic Risk Score; Risk Prediction Model; GWAS; Polygenic risk score; in silico QC解析; genotype imputation; がん予防; リスク予測モデル

项目成果

国立がん研究センター 予防研究グループ 多目的コホート研究

国家癌症中心预防研究小组多用途队列研究

Polygenic risk scores for prediction of breast cancer risk in Asian populations.

• DOI: 10.1016/j.gim.2021.11.008
• 发表时间: 2022-03
• 期刊: Genetics in medicine : official journal of the American College of Medical Genetics
• 作者: Ho WK;Tai MC;Dennis J;Shu X;Li J;Ho PJ;Millwood IY;Lin K;Jee YH;Lee SH;Mavaddat N;Bolla MK;Wang Q;Michailidou K;Long J;Wijaya EA;Hassan T;Rahmat K;Tan VKM;Tan BKT;Tan SM;Tan EY;Lim SH;Gao YT;Zheng Y;Kang D;Choi JY;Han W;Lee HB;Kubo M;Okada Y;Namba S;BioBank Japan Project;Park SK;Kim SW;Shen CY;Wu PE;Park B;Muir KR;Lophatananon A;Wu AH;Tseng CC;Matsuo K;Ito H;Kwong A;Chan TL;John EM;Kurian AW;Iwasaki M;Yamaji T;Kweon SS;Aronson KJ;Murphy RA;Koh WP;Khor CC;Yuan JM;Dorajoo R;Walters RG;Chen Z;Li L;Lv J;Jung KJ;Kraft P;Pharoah PDB;Dunning AM;Simard J;Shu XO;Yip CH;Taib NAM;Antoniou AC;Zheng W;Hartman M;Easton DF;Teo SH
• 通讯作者: Teo SH

1.FTO gene polymorphism, plasma levels of leptin and adiponectin, and the risk of colorectal cancer.

1.FTO基因多态性、血浆瘦素、脂联素水平与结直肠癌风险。

• 发表时间: 2020
• 作者: Taiki Yamaji;Motoki Iwasaki;Norie Sawada;Taichi Shimazu;Manami Inoue;Shoichiro Tsugane.
• 通讯作者: Shoichiro Tsugane.

Identification of two novel breast cancer loci through large-scale genome-wide association study in the Japanese population

• DOI: 10.1038/s41598-019-53654-9
• 发表时间: 2019-11-22
• 期刊: SCIENTIFIC REPORTS
• 影响因子: 4.6
• 作者: Low, Siew-Kee;Chin, Yoon Ming;Miki, Yoshio
• 通讯作者: Miki, Yoshio

Population-specific and trans-ancestry genome-wide analyses identify distinct and shared genetic risk loci for coronary artery disease

• DOI: 10.1038/s41588-020-0705-3
• 发表时间: 2020-10-05
• 期刊: NATURE GENETICS
• 影响因子: 30.8
• 作者: Koyama, Satoshi;Ito, Kaoru;Komuro, Issei
• 通讯作者: Komuro, Issei