Genetische Analyse muzinöser Pankreasneoplasien

胰腺囊性肿瘤（CNP）是目前胰腺切除术最常见的适应症之一，研究CNP是对抗胰腺癌的重要手段。有十几种不同的CNP，但它们大多由浆液性囊腺瘤、粘液性囊性肿瘤（MCN）和导管内乳头状粘液性肿瘤（IPMN）组成。IPMN和MCN都衬有粘液上皮，可以表现出不同程度的炎症，毫无疑问，它们可以窝藏胰腺癌。由于IPMN或MCN的癌症患者比胰腺导管癌患者年龄大5-12岁，并且他们的生存率要好得多，这表明IPMN中产生的癌症是一种更容易治愈的不同疾病。此外，在主管IPMN和MCN中，癌症的频率似乎远高于分支导管IPMN。我们建议使用高分辨率的微阵列技术来确定主和分支导管IPMNs之间的关系，IPMNs和MCN之间，以及这些病变和更常见的胰腺导管癌之间。这些差异可以部分解释这些肿瘤的不同临床行为。假设：主、分支IPMN、MCN和普通胰腺导管癌在遗传上是不同的，这些差异可能部分地构成了它们的临床行为的基础。

An important means in the battle against pancreatic cancer is the study of cystic neoplasms of the pancreas (CNP), which are currently one of the most common indications for pancreatic resection. There are over a dozen different CNP, however they mostly are comprised by serous cystadenomas, mucinous cystic neoplasms (MCN), and intraductal papillary mucinous neoplasms (IPMNs). Both IPMNs and MCN are lined by mucinous epithelium that can exhibit various degrees of atypia and there is no question that they can harbour pancreatic carcinoma. As IPMN or MCN patients with carcinoma were 5-12 years older than those with pancreatic ductal carcinoma and their survival is much better, it is suggested that cancer arising in IPMN is a different disease which is more amenable to cure. Furthermore, in main duct IPMN and MCN, the frequency of cancer appears to be much higher than in branch duct IPMNs. We propose to use high-resolution microarray techniques to determine the relation between main and branch duct IPMNs, between IPMNs and MCN, and between these lesions and the more common pancreatic ductal carcinoma. These differences may in part explain the distinct clinical behaviour of these tumors. Hypothesis: Main and branch IPMNs, MCN and common pancreatic ductal carcinoma are genetically distinct, and these differences may in part underlie their clinical behaviour.