Development of a physics-based fast screening method for detecting the cancer-therapeutic peptides

开发基于物理的快速筛选方法来检测癌症治疗肽

• 批准号: 19K14674
• 负责人: Hayashi Tomohiko
• 金额: $ 2.75万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K14674/
• 关键词: ペプチド抗癌剤; 天然変性ペプチド; 自由エネルギー計算; 水和自由エネルギー; 積分方程式理論; 形態計測学的アプローチ; 自由エネルギー関数

项目成果

Development of an Outward Proton Pumping Rhodopsin with a New Record in Thermostability by Means of Amino Acid Mutations

通过氨基酸突变开发出具有热稳定性新记录的外向质子泵视紫红质

• DOI: 10.1021/acs.jpcb.1c08684
• 发表时间: 2022
• 期刊: The Journal of Physical Chemistry B
• 作者: Yasuda Satoshi;Akiyama Tomoki;Kojima Keiichi;Ueta Tetsuya;Hayashi Tomohiko;Ogasawara Satoshi;Nagatoishi Satoru;Tsumoto Kouhei;Kunishima Naoki;Sudo Yuki;Kinoshita Masahiro;Murata Takeshi
• 通讯作者: Murata Takeshi

Statistical thermodynamics on the weakening of binding affinity of myosin for actin at low temperatures

低温下肌球蛋白与肌动蛋白结合力减弱的统计热力学

• 发表时间: 2021
• 作者: Tomohiko Hayashi;Masahiro Kinoshita
• 通讯作者: Masahiro Kinoshita

Structural and physical basis for anti-prion activity and destruction of the Alzheimer’s disease-related complex of an RNA-aptamer

RNA适体的抗朊病毒活性和破坏阿尔茨海默病相关复合物的结构和物理基础

• 发表时间: 2021
• 作者: Takashi Nagata;Tsukasa Mashima;Joon-Hwa Lee;Yuji O. Kamatari;Tomohiko Hayashi;Masahiro Kinoshita;Kazuo Kuwata;Masato Katahira
• 通讯作者: Masato Katahira

Calculation of hydration free energy of a protein with sufficient accuracy and remarkably high speed

以足够的精度和非常高的速度计算蛋白质的水合自由能

• 发表时间: 2021
• 作者: Masato Kawamura;Shunsuke Miyamoto;Tomohiko Hayashi;Masahiro Kinoshita
• 通讯作者: Masahiro Kinoshita

Structural and Physical Basis for the Higher Affinity to Oncoprotein MDM2 of a Peptide Selected with MRNA Display Over Tumor Suppressor p53

与肿瘤抑制因子 p53 相比，通过 mRNA 显示选择的肽与癌蛋白 MDM2 具有更高亲和力的结构和物理基础

• 发表时间: 2019
• 作者: Takashi Nagata;Tatsuya Yamada;Tomohiko Hayashi;Simon Hikiri;Naohiro Kobayashi;Mitsunori Ikeguchi;Masato Katahira;Masahiro Kinoshita;Hiroshi Yanagawa
• 通讯作者: Hiroshi Yanagawa