Anomalous Michaelis-Menten kinetics in crowded environments (C03/Erg.)

拥挤环境中的异常 Michaelis-Menten 动力学 (C03/Erg.)

• 批准号: 355497160
• 金额: --
• 依托单位: Institut für Mathematik
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/355497160?language=en
• 关键词: Anomalous; Michaelis; Menten; kinetics; crowded

The diffusion of macromolecules (e. g., proteins) in the interior of living cells differs significantly from that in dilute solutions, which is commonly attributed to the dense packing of cells (“macromolecular crowding”). A cascade of time and length scales governs this anomalous transport and is expected to render the kinetics of chemical reactions anomalous as well. This project is to study the Michaelis-Menten kinetics in the crowded environment of the Lorentz model, combining large-scale simulations of the microscopic model, scaling theory, spatio-temporal chemical master equations, and effective medium theory.

大分子的扩散（e.例如，在一个实施例中，活细胞内部的蛋白质）与稀释溶液中的显著不同，这通常归因于细胞的密集堆积（“大分子拥挤”）。一系列的时间和长度尺度控制着这种异常的传输，预计也会使化学反应的动力学异常。本项目结合微观模型、标度理论、时空化学主方程和有效介质理论的大规模模拟，研究洛伦兹模型拥挤环境下的Michaelis-Menten动力学。