Ganzkörper Hybrid PET/MR Tomograph

全身PET/MR由于结合了形态学、生理学和分子成像而引起了很大的期望。第一代用户成功地评估了PET/MR的一般方面和可行性。最近，第二代扫描仪进行了实质性改进。对于乌尔姆大学来说，这是加入PET/MR社区的理想时机，因为我们的临床和科学专业知识非常适合扩展PET/MR智能和创新应用的知识。该系统将作为“核心设施”运行，因此将研究各种各样的项目。然而，临床和转化研究的两个主要主题将成为我们的重点：PET/MR常规适应症的评估，设计有效的工作流程，以促进临床整合。在这里，CCCU（综合癌症中心乌尔姆）的基础设施将特别有益。此外，评估“多模态多参数成像”或“mMPI”的概念，即对组织生物学的多个定量数据的整体分析，其可以通过PET/MR非侵入性地提取并且例如用于治疗规划、预后评估或响应评估。将形成以下6个项目领域：神经科学（A）、心血管科学（B）、肿瘤学（C）、儿科学（D）、传染病和肌肉骨骼疾病（E）以及核心项目医学物理学和仪器（F）。乌尔姆大学在每个领域都拥有特殊的专业知识，保证了PET/MR的成功实施和出色的科学产出。

Whole-body PET/MR raises great expectations due to the combination of morphological, physiological and molecular imaging. The first generation of users successfully evaluated the general aspects and feasibility of PET/MR. Recently, the second generation of scanners was introduced with substantial improvements. For Ulm University, this is the ideal time to join the PET/MR community, as our clinical and scientific expertise is well suited for extending the knowledge on intelligent and innovative applications of PET/MR. The system will be run as a “core facility”, thus a broad variety of projects will be investigated. However, two main topics from clinical and translational research will be in our focus: evaluation of routine indications for PET/MR with design of efficient workflows to facilitate integration in the clinics. Here, the infrastructure of the CCCU (comprehensive cancer center Ulm) will be especially beneficial. Moreover, evaluation of the concept of “multimodal multiparametric imaging” or “mMPI”, i.e. the integral analysis of the multiple quantitative data on tissue biology, which can be extracted non-invasively by PET/MR and be used e.g. for therapy planning, prognostic assessment or response evaluation. The following 6 project areas will be formed: Neurosciences (A), Cardiovascular sciences (B), Oncology (C), Pediatrics (D), Infectious and musculoskeletal diseases (E) and the Core project medical physics and instrumentation (F). In each of these areas, special expertise is present at Ulm University, guaranteeing a successful implementation of PET/MR with excellent scientific output.