The role of pericytes in the development of epileptogenesis after traumatic brain injury
The role of pericytes in the development of epileptogenesis after traumatic brain injury
批准号:
18K06712
负责人:
TAKATA Fuyuko
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2018
资助国家:
日本
项目状态:
已结题
起止时间:
2018-04-01 至 2021-03-31
中文摘要
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英文摘要
期刊论文(9)
专著(0)
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頭部外傷後の脳ペリサイトPDGFRβシグナル阻害は、pilocarpineけいれん発作の感受性を減弱させる
头部创伤后脑周细胞 PDGFRβ 信号抑制减弱毛果芸香碱癫痫发作易感性
DOI:
--
发表时间:
2019
期刊:
影响因子:
--
作者:
[坂井研太, 高田芙友子, 冨永一樹, 橋口夏奈, 安永美保, 山内淳史, 道具伸也, 片岡泰文]
通讯作者:
片岡泰文
Dysregulation of the CNS supporting vascular and glial cells induces the late posttraumatic epilepsy in mice with mild traumatic brain injury.
支持血管和神经胶质细胞的中枢神经系统失调会诱发轻度创伤性脑损伤小鼠的晚期创伤后癫痫。
DOI:
--
发表时间:
2018
期刊:
影响因子:
--
作者:
[Kenta Sakai, Fuyuko Takata, Shinya Dohgu, Mitsuhisa Koga, Ikuya Kimura, Atsushi Yamauchi, Yasufumi Kataoka.]
通讯作者:
Yasufumi Kataoka.
Enhanced glutamate uptake in the astrocytes cocultured with brain pericytes.
与脑周细胞共培养的星形胶质细胞中谷氨酸的摄取增强。
DOI:
--
发表时间:
2021
期刊:
影响因子:
--
作者:
[Fuyuko Takata, Kenta Sakai, Takuro Iwao, Atsushi Yamauchi, Yasufumi Kataoka, Shinya Dohgu]
通讯作者:
Shinya Dohgu
10.Increased PDGFRβ expression of the pericytes in the early stage after traumatic brain injury is a major cause of the subsequent activation of microglia and hypersusceptibility to pilocarpine-induced seizure in mice.
10.脑外伤后早期周细胞PDGFRβ表达增加是随后小胶质细胞激活和对毛果芸香碱诱发的小鼠癫痫发作高度敏感的主要原因。
DOI:
--
发表时间:
2019
期刊:
影响因子:
--
作者:
[Fuyuko Takata, Kenta Sakai, Atsushi Yamauchi, Shinya Dohgu, Yasufumi Kataoka]
通讯作者:
Yasufumi Kataoka
12.PDGFRβ signal inhibition in brain pericytes suppresses glial activation and increased seizure susceptibility to pilocarpine in mice with traumatic brain injury.
12.脑外伤性脑损伤小鼠脑周细胞中的PDGFRβ信号抑制可抑制神经胶质细胞活化并增加毛果芸香碱癫痫发作的易感性。
DOI:
--
发表时间:
2019
期刊:
影响因子:
--
作者:
[Kenta Sakai, Fuyuko Takata, Yoshie Tanaka, Yume Sezaki, Kazuki Tominaga, Kana Hashiguchi, Miho Yasunaga, Atsushi Yamauchi, Shinya Dohgu, Yasufumi Kataoka.]
通讯作者:
Yasufumi Kataoka.
共 8 条
A key role of the brain pericytes in the induction and development of brain inflammation under the pathophysiological conditions of obesity-associated diabetes.
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批准号:26460113
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.24万
-
财政年份:2014
-
负责人:TAKATA Fuyuko
-
依托单位:
Involvement of pericytes-derived cyclophilin A in the development of insulin resistanse in the brain
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批准号:23790113
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.83万
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财政年份:2011
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负责人:TAKATA Fuyuko
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依托单位:
Involvement of brain pericytes in the development of obesity
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批准号:21790102
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.66万
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财政年份:2009
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负责人:TAKATA Fuyuko
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依托单位:
海外基金