Targeting α5β1 integrin for imaging of tumor angiogenesis and antiangiogenic therapy (A10)

虽然跨膜受体αvβ3整合素几十年来一直被认为是血管生成活性的特异性细胞标志物，但最近的数据表明α5β1整合素可能更适合这一目的。本项目旨在挖掘α5β1整合素作为新型成像探针和抗血管生成放射治疗靶点的潜力，并阐明α5β1整合素表达与其他血管生成标志物（如αvβ3整合素或癌胎纤维连接蛋白的癌胎片变体外域B）表达的相互作用和相关性。

Although the transmembrane receptor αvβ3 integrin has been considered a specific cellular marker for angiogenic activity for decades, recent data suggest that the α5β1 integrin might be more suitable for this purpose. This project aims to exploit the potential of α5β1 integrin as a target for novel imaging probes and antiangiogenic radiotherapeutics, and to elucidate interplay and correlation of α5β1 integrin expression with that of other angiogenesis markers, such as αvβ3 integrin or the oncofetal slice variant of fibronectin, extradomain B.