TRR 57: Organ Fibrosis: From Mechanisms of Injury to Modulation of Disease

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The aim of the project is to prevent liver fibrosis by inhibiting the cell cycle of pro-fibrotic cells such as hepatic stellate cells (HSC) or immune cells. Initiation of liver fibrosis is associated with increased activity of the cell cycle protein Cyclin E1. We will investigate the function of Cyclin E1 during alcoholic liver disease (ALD), which is one of the most prevalent risk factors for liver fibrosis. We will further characterize the role of Cyclin E1 in immune cells for fibrosis initiation and develop novel anti-fibrotic treatment strategies by HSC-specific delivery of a pharmacological Cdk inhibitor.