TRR 57: Organ Fibrosis: From Mechanisms of Injury to Modulation of Disease

该项目的目的是通过抑制肝星状细胞（HSC）或免疫细胞等促纤维化细胞的细胞周期来预防肝纤维化。肝纤维化的发生与细胞周期蛋白Cyclin E1活性的增加有关。我们将研究Cyclin E1在酒精性肝病（ALD）中的功能，这是肝纤维化最普遍的危险因素之一。我们将进一步表征Cyclin E1在免疫细胞纤维化起始中的作用，并通过hsc特异性递送Cdk药理学抑制剂来开发新的抗纤维化治疗策略。

The aim of the project is to prevent liver fibrosis by inhibiting the cell cycle of pro-fibrotic cells such as hepatic stellate cells (HSC) or immune cells. Initiation of liver fibrosis is associated with increased activity of the cell cycle protein Cyclin E1. We will investigate the function of Cyclin E1 during alcoholic liver disease (ALD), which is one of the most prevalent risk factors for liver fibrosis. We will further characterize the role of Cyclin E1 in immune cells for fibrosis initiation and develop novel anti-fibrotic treatment strategies by HSC-specific delivery of a pharmacological Cdk inhibitor.