Interaction between stress and serotonergic signaling pathways to modulate extinction learning in the amygdala (A07)

杏仁核已被确定为参与包括焦虑和恐惧的情绪行为的记忆处理的主要神经元回路之一，并且是大脑中用于处理应激反应的关键组成部分之一。因此，我们将研究杏仁核内的多巴胺能信号通路在正常和应激条件下的厌恶学习和消退中的作用。利用光激活G蛋白偶联受体（GPCR），我们将对杏仁核内小白蛋白阳性中间神经元和海马锥体神经元在恐惧记忆形成和消退学习过程中的5 HT 2A/2C受体信号通路进行光遗传学调控。我们想研究这些受体如何调节恐惧条件反射，灭绝，更新和恢复在正常和压力条件下。

The amygdala has been identified as one of the main neuronal circuits involved in the processing of memories of emotional behavior including anxiety and fear and is one of the key components in the brain for processing stress responses. Thus, we will investigate the role of serotonergic signaling pathways within the amygdala for aversive learning and extinction under normal and stress conditions. By using light-activated G protein-coupled receptors (GPCR), we will optogenetically control 5 HT2A/2C receptor signaling pathways in parvalbumin positive interneurons and glutamatergic pyramidal neurons during fear memory formation and extinction learning in the amygdala. We want to investigate how these receptors modulate fear conditioning, extinction, renewal and reinstatement under normal and stress conditions.