The neurobiology of operant behavior

操作行为的神经生物学

• 批准号: 373335476
• 负责人: Professor Dr. Björn Brembs
• 金额: --
• 依托单位: Institut für Zoologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/373335476?language=en
• 关键词: neurobiology; operant; behavior

Over the last 15 years, the neurosciences have been adopting the perspective that the functional principle of all brains is one of constant ongoing activity. External stimuli merely modulate this activity and may be able to guide it towards specific patterns. How brains are generating these constantly fluctuating patterns of ongoing activity is still largely unclear. In this proposal we first build on our previous work in the fruit fly Drosophila, suggesting a critical role for a group of ellipsoid-body neurons in the brain of the fly for the temporal structure of spontaneous behavior. Moreover, we apply to use the modification of spontaneous behavior by reafferent feedback from behavioral outcomes to learn more about the neuronal control of spontaneous behavior. For this work we propose to use neurogenetic methods such as optogenetics and computerized analysis of the behavior of transgenic animals. Ultimate goal of the proposed research is to use this two-pronged approach to come to a fundamental, mechanistic understanding of the neuronal control of spontaneous behavior, both via internal and external factors.

在过去的15年里，神经科学一直采用这样一种观点，即所有大脑的功能原理都是一种持续不断的活动。外部刺激只是调节这种活动，并可能引导它走向特定的模式。大脑是如何产生这些不断波动的持续活动模式的，在很大程度上仍然不清楚。在这个建议中，我们首先建立在我们以前的工作在果蝇果蝇，这表明一组椭圆体神经元在苍蝇的自发行为的时间结构的大脑中的关键作用。此外，我们应用行为结果的传入反馈对自发行为的修改来了解更多关于自发行为的神经元控制。对于这项工作，我们建议使用神经遗传学方法，如光遗传学和计算机分析的转基因动物的行为。拟议研究的最终目标是使用这种双管齐下的方法，通过内部和外部因素对自发行为的神经元控制进行基本的机械理解。