Reticuloendothelial system blockade by PEG-oligo(amino acid) block copolymers: A strategy for functional tuning of nanomedicine pharmacokinetics

PEG-寡聚（氨基酸）嵌段共聚物阻断网状内皮系统：纳米药物药代动力学功能调节的策略

• 批准号: 18K18393
• 负责人: Dirisala Anjaneyulu
• 金额: $ 2.58万
• 依托单位: Kawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2018
• 资助国家: 日本
• 起止时间: 2018-04-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18K18393/
• 关键词: RES blockade; PEG coating to liver; Two-arm-PEG-peptide; Bile clearance; Retargeting nanomedicine; Reticuloendothelium; Sinusoidal wall; Two-arm-PEG-OligoLysine; Liver blockade; Single arm PEG-OLys; Double arm PEG-OLys; PEG-oligo(amino acid)

项目成果

体内における薬物動態を制御する組成物

控制体内药代动力学的组合物

• 发表时间: 2019

Composition controlling pharmacokinetics in the body

控制体内药代动力学的组合物

• 发表时间: 2020

mRNA loading into ATP-responsive polyplex micelles with optimal density of phenylboronate ester crosslinking to balance robustness in the biological milieu and intracellular translational efficiency

• DOI: 10.1016/j.jconrel.2020.12.033
• 发表时间: 2021-02-10
• 期刊: JOURNAL OF CONTROLLED RELEASE
• 影响因子: 10.8
• 作者: Yoshinaga, Naoto;Uchida, Satoshi;Kataoka, Kazunori
• 通讯作者: Kataoka, Kazunori

Liver sinusoidal blockade by poly(ethylene glycol)－oligo(amino acid) block copolymers for tuning pharmacokinetics of NanoMedicine

聚(乙二醇)-寡(氨基酸)嵌段共聚物阻断肝窦以调节纳米药物的药代动力学

• 发表时间: 2019
• 作者: Anjaneyulu Dirisala;Satoshi Uchida;Kazuko Toh;Shigehito Osawa;Kotaro Hayashi;Kazunori Kataoka
• 通讯作者: Kazunori Kataoka

Effect of poly(ethylene glycol) molecular weight for overcoming liver sinusoidal barrier towards prolonged circulation activity of polyplex micelles

聚乙二醇分子量对克服肝窦屏障对延长复合胶束循环活性的影响

• 发表时间: 2018
• 作者: Dirisala Anjaneyulu; Kensuke Osada;Kazuko Toh;Theofilus A. Tockary;Satoshi Uchida;Horacio Cabral;Kazunori Kataoka
• 通讯作者: Kazunori Kataoka