Establishing 3-dimentional structure of trachea and esophageal organoid toward understanding the mechanism underlying mesenchymal polarization

建立气管和食管类器官的三维结构以了解间充质极化的机制

• 批准号: 18KK0423
• 负责人: Kishimoto Keishi
• 金额: $ 9.98万
• 依托单位: Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019 至 2022
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18KK0423/
• 关键词: オルガノイド; 気管; 食道; 間充織; ヒトES細胞; 内胚葉; 中胚葉; 呼吸器; 極性

项目成果

Understanding early respiratory and esophageal development toward in vitro modeling organogenesis with human pluripotent stem cells

了解早期呼吸和食管发育，以利用人类多能干细胞进行体外器官发生建模

• 发表时间: 2022
• 作者: Kishimoto K;Zorn AM and Morimoto M
• 通讯作者: Zorn AM and Morimoto M

ORGANOID MESODERM LINEAGE DIVERSIFICATION

类器官中胚层谱系多样化

• 发表时间: 2020

Bidirectional Wnt signaling between endoderm and mesoderm confer tracheal identity in mouse and human

内胚层和中胚层之间的双向 Wnt 信号传导赋予小鼠和人类气管身份

• DOI: 10.1101/758235
• 发表时间: 2020
• 期刊: Biorxiv
• 作者: Keishi Kishimoto;Kana T. Furukawa;Agustin Luz Madrigal;Akira Yamaoka;Chisa Matsuoka;Masanobu Habu;Cantas Alev;Aaron M. Zorn;Mitsuru Morimoto
• 通讯作者: Mitsuru Morimoto

Understanding and recapitulating trachea-esophageal development

了解并概括气管食管发育

• 发表时间: 2023
• 作者: Keishi Kishimoto;Aaron M Zorn;Mitsuru Morimoto
• 通讯作者: Mitsuru Morimoto

Directed differentiation of human pluripotent stem cells into diverse organ-specific mesenchyme of the digestive and respiratory systems.

• DOI: 10.1038/s41596-022-00733-3
• 发表时间: 2022-11
• 期刊: NATURE PROTOCOLS
• 影响因子: 14.8
• 作者: Kishimoto, Keishi;Iwasawa, Kentaro;Sorel, Alice;Ferran-Heredia, Carlos;Han, Lu;Morimoto, Mitsuru;Wells, James M.;Takebe, Takanori;Zorn, Aaron M.
• 通讯作者: Zorn, Aaron M.