A Novel fabrication of dissoluble microneedle Patch for bio-medical applications and monitoring

用于生物医学应用和监测的可溶性微针贴片的新型制造

• 批准号: 19F19725
• 负责人: 金 範ジュン
• 金额: $ 1.47万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for JSPS Fellows
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-25 至 2021-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19F19725/
• 关键词: マイクロニードル; バイオセンサー; グルコースセンサー; 生体分解性ポリマー; 低侵襲血糖値センサー; DDS

本研究の目的は、生体分解性かつ多孔質のマイクロニードルを製作し、DDS応用ではなく、生体内の物質（例え、細胞間体質）を吸収できるニードルアレーを製作することで、様々な生体分解性ポリマーを用いた多孔質マイクロニードルの製作方法を最適化、確立し、大量生産が可能な最適化製造基盤を目指した。Monitoring chemical and biological compositions of bio-fluids in human body is a key parameter of for diagnosing diseases nowadays. For continuous monitoring, a promising candidate is the porous microneedles. Porous microneedles made of biodegradable and bio-compatible materials, processed to make them porous are attractive alternative for continuous sensing and diagnosis of bio-fluids.In this research, glucose sensing through the microneedles were achieved using the experimental array presented previously. Indeed, a better understanding of the mechanism involved in the fluid collection was achieved as well as an optimization of the process: temperature of treatment, ratio porogen/material. Full characterization of the device including mechanical strength, fluid intake, SEM observation has been done.

The purpose of this study is to optimize, establish, and mass-produce a method for producing a biodegradable porous substrate, a DDS substrate, and a substrate for absorbing substances (e.g., cell-to-cell constitutions) in the organism. Monitoring chemical and biological compositions of bio-fluids in human body is a key parameter of for diagnosing diseases nowadays. For continuous monitoring, a promising candidate is the porous microneedles. Porous microneedles made of biodegradable and bio-compatible materials, processed to make them porous are attractive alternative for continuous sensing and diagnosis of bio-fluids.In this research, glucose sensing through the microneedles were achieved using the experimental array presented previously. Indeed, a better understanding of the mechanism involved in the fluid collection was achieved as well as an optimization of the process: temperature of treatment, ratio porogen/material. Full characterization of the device including mechanical strength, fluid intake, SEM observation has been done.

项目成果

kimlab

金拉布

Biodegradable porous microneedles via PLA microspheres for rapid ISF extraction

通过 PLA 微球可生物降解的多孔微针，用于快速 ISF 提取

• 发表时间: 2021
• 作者: Leilei Bao;Jongho Park;Gwenael Bonfante;Hakjae Lee;Beomjoon Kim
• 通讯作者: Beomjoon Kim

Biodegradable microneedles for bio-sensing application

用于生物传感应用的可生物降解微针

• 发表时间: 2020
• 作者: Gwenael Bonfante;Hakjae Lee;Leilei Bao;Jongho Park;Beomjoon Kim
• 通讯作者: Beomjoon Kim

PLGA Porous Microneedles for Interstitial Fluid Collection Aimed for Continuous Glucose Sensing

用于间质液收集的 PLGA 多孔微针旨在实现连续血糖传感

• 发表时间: 2020
• 作者: Gwenael Bonfante;Hakjae Lee;Leilei Bao;Nobuyuki Takama;Beomjoon Kim
• 通讯作者: Beomjoon Kim

Fabrication of a Hydrogel Microneedle Array for Glucose Monitoring

用于血糖监测的水凝胶微针阵列的制造

• 发表时间: 2020
• 作者: Gwenael Bonfante;Hakjae Lee;Leilei Bao;Jongho Park;Nobuyuki Takama;Beomjoon Kim
• 通讯作者: Beomjoon Kim