A Novel fabrication of dissoluble microneedle Patch for bio-medical applications and monitoring

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本研究の目的は、生体分解性かつ多孔質のマイクロニードルを製作し、DDS応用ではなく、生体内の物質（例え、細胞間体質）を吸収できるニードルアレーを製作することで、様々な生体分解性ポリマーを用いた多孔質マイクロニードルの製作方法を最適化、確立し、大量生産が可能な最適化製造基盤を目指した。Monitoring chemical and biological compositions of bio-fluids in human body is a key parameter of for diagnosing diseases nowadays. For continuous monitoring, a promising candidate is the porous microneedles. Porous microneedles made of biodegradable and bio-compatible materials, processed to make them porous are attractive alternative for continuous sensing and diagnosis of bio-fluids.In this research, glucose sensing through the microneedles were achieved using the experimental array presented previously. Indeed, a better understanding of the mechanism involved in the fluid collection was achieved as well as an optimization of the process: temperature of treatment, ratio porogen/material. Full characterization of the device including mechanical strength, fluid intake, SEM observation has been done.