Involvement of 12alpha-hydroxylated bile acids in the onset and aggravation of fatty liver

12α-羟基化胆汁酸参与脂肪肝的发生和加重

• 批准号: 19H02900
• 负责人: ISHIZUKA Satoshi
• 金额: $ 11.32万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19H02900/
• 关键词: 胆汁酸; 脂肪肝; 12α水酸化胆汁酸; bile acids; liver lipid accumulation

项目成果

Gachon University(韓国)

嘉泉大学（韩国）

Association between 12α-hydroxylated bile acids and hepatic steatosis in rats fed a high-fat diet

• DOI: 10.1016/j.jnutbio.2020.108412
• 发表时间: 2020-09-01
• 期刊: JOURNAL OF NUTRITIONAL BIOCHEMISTRY
• 影响因子: 5.6
• 作者: Hori, Shota;Abe, Takayuki;Ishizuka, Satoshi
• 通讯作者: Ishizuka, Satoshi

An increase of 12α-hydroxylated bile acid is associated with hepatic steatosis induced by a high-fat diet in rats.

12α-羟基化胆汁酸的增加与高脂肪饮食引起的大鼠肝脂肪变性有关。

• 发表时间: 2019
• 作者: Hori S;Satake M;Abe T;Hara H;Fukiya S;Yokota A;Ishizuka S.
• 通讯作者: Ishizuka S.

Amelioration of hepatic steatosis by ingestion of raffinose via modulation of bile acid metabolism in rats.

通过调节大鼠胆汁酸代谢摄入棉子糖改善肝脏脂肪变性。

• 发表时间: 2019
• 作者: Maegawa K;Ishizuka S.
• 通讯作者: Ishizuka S.

A low coefficient of variation in hepatic triglyceride concentration in an inbred rat strain

近交系大鼠肝甘油三酯浓度的变异系数较低

• DOI: 10.1186/s12944-020-01320-9
• 发表时间: 2020
• 期刊: Lipids in Health and Disease
• 影响因子: 4.5
• 作者: Shimoda T;Hori S;Maegawa K;Takeuchi A;Lee Y;Joe GH;Tanaka Y;Shimizu H;Ishizuka S.
• 通讯作者: Ishizuka S.