Structural determination of respiratory membrane protein complexes by X-ray crystallography

X 射线晶体学测定呼吸膜蛋白复合物的结构

• 批准号: DP0666970
• 负责人: A/Prof Mika Jormakka
• 金额: $ 26.08万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-06-01 至 2008-11-21
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0666970
• 关键词: Structural; determination; respiratory; membrane; protein

Membrane proteins form only 0.3% of the available protein structures in the protein data bank (PDB), yet 30% of the proteins in the human genome and 50% of human drug targets are membrane proteins. We have managed to increase the success rate through rational screening and development of new crystallization screens, with downstream implications for basic and medical research. Results from this proposal will receive international recognition and will encourage more research in this field, attracting international funding, and create new research opportunities.

在蛋白质数据库（PDB）中，膜蛋白仅占可用蛋白质结构的0.3%，但人类基因组中30%的蛋白质和50%的人类药物靶点是膜蛋白。我们通过合理筛选和开发新的结晶筛，成功地提高了成功率，并对基础和医学研究产生了下游影响。该提案的成果将得到国际认可，并将鼓励在这一领域进行更多的研究，吸引国际资金，并创造新的研究机会。