The role of adiponectin in the regulation of hypothalamic circadian rhythms

脂联素在调节下丘脑昼夜节律中的作用

• 批准号: 386891684
• 负责人: Professor Dr. Henrik Oster
• 金额: --
• 依托单位: Institut für Neurobiologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/386891684?language=en
• 关键词: role; adiponectin; regulation; hypothalamic; circadian

Endogenous circadian clocks regulate physiology and behaviour along the 24-h day cycle. The circadian system and energy metabolism are tightly coupled. Central and peripheral circadian clocks coordinate key metabolic processes and the 24-h rhythms of food intake and energy expenditure. On the other hand, metabolic state can reset circadian rhythms in the periphery and the central nervous system - and in this way adapt physiological functions. The mechanisms of this metabolism-clock feedback will be studied in this project. We will use different transgenic mouse models to analyse the effect of adipose tissue-derived signals on circadian physiological and behavioural rhythms and clocks in energy metabolism-regulatory centres of the hypothalamus.

内源性生物钟沿着24小时的昼夜周期调节生理和行为。昼夜节律系统和能量代谢是紧密耦合的。中枢和外周生物钟协调关键的代谢过程以及食物摄入和能量消耗的24小时节律。另一方面，代谢状态可以重置外周和中枢神经系统的昼夜节律-并以这种方式适应生理功能。本计画将研究此代谢时钟回馈的机制。我们将使用不同的转基因小鼠模型来分析脂肪组织来源的信号对下丘脑能量代谢调节中心的昼夜生理和行为节律和时钟的影响。

项目成果

An adipokine feedback regulating diurnal food intake rhythms in mice

• DOI: 10.7554/elife.55388
• 发表时间: 2020-07-09
• 期刊: ELIFE
• 影响因子: 7.7
• 作者: Tsang, Anthony H.;Koch, Christiane E.;Oster, Henrik
• 通讯作者: Oster, Henrik

Circadian clock rhythms in different adipose tissue model systems

• DOI: 10.1080/07420528.2018.1494603
• 发表时间: 2018-11-02
• 期刊: CHRONOBIOLOGY INTERNATIONAL
• 影响因子: 2.8
• 作者: Friedrichs, Maureen;Kolbe, Isa;Oster, Henrik
• 通讯作者: Oster, Henrik

Generation of Mouse Primary Hypothalamic Neuronal Cultures for Circadian Bioluminescence Assays.

用于昼夜节律生物发光测定的小鼠原代下丘脑神经元培养物的生成

• DOI: 10.21769/bioprotoc.3944
• 发表时间: 2021
• 期刊: Bio-protocol
• 影响因子: 0.8
• 作者: Schmidt CX;Tsang AH;Oster H
• 通讯作者: Oster H