Spatial and temporal targeting of membrane-bound mPGES-1 and FLAP / 5-LO by dual inhibitors employing polymer-based nanocarriers (A04)

A04项目旨在建立新的、更有效的消炎药物，特别是微粒体前列腺素E2合成酶-1(mPGES-1)和5-脂氧合酶激活蛋白(FLAP)或5-脂氧合酶(5-LO)的双重抑制物。使用聚合物颗粒作为纳米载体将实现提高药物的生物利用度和靶向递送。现场的药物输送将利用先进的荧光显微镜在单核细胞来源的巨噬细胞和更复杂的生物系统中进行研究。

Project A04 aims at establishing novel and more effective drugs for resolving inflammation, specifically of dual inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase-activating protein (FLAP) or 5-lipoxygenase (5-LO). Improved bioavailability and target-specific delivery of the drug will be realised employing polymer particles as nanocarriers. Drug delivery at site will be investigated utilising advanced fluorescence microscopy both in monocyte-derived macrophages and more complex biosystems.