The role of heparan sulfate proteoglycans during zebrafish bone regeneration (B11*)

Knopf和M.Brand以斑马鱼为模型，重点研究骨再生和糖皮质激素性骨质疏松症(GIO)。他们的目标是研究成纤维细胞生长因子(成纤维细胞生长因子)信号通路及其与硫酸乙酰肝素蛋白多糖(HSPG)的相互作用，并建立成纤维细胞生长因子的形态发生梯度，因为它们对正常和骨质疏松的骨再生具有重要意义。这些结果为HSPG和FGFs在创伤后成人骨再生过程中的相互作用以及糖皮质激素的调节提供了深入的认识。

F. Knopf and M. Brand focus on the bone regeneration and glucocorticoid-induced osteoporosis (GIO) using zebrafish as a model. Their goals are to investigate the FGF (fibroblast growth factor) signaling pathway and the interaction of FGF with heparan sulfate proteoglycans (HSPG), and to establish FGF morphogenetic gradients, because of their importance for normal and osteoporotic bone regeneration. These results provide insights into the interaction of HSPG and FGFs during adult bone regeneration after trauma and its modulation by glucocorticoids.