The role of heparan sulfate proteoglycans during zebrafish bone regeneration (B11*)

硫酸乙酰肝素蛋白多糖在斑马鱼骨再生过程中的作用 (B11*)

• 批准号: 387653785
• 金额: --
• 依托单位: Zentrum für Regenerative Therapien Dresden - CRTD
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/387653785?language=en
• 关键词: role; heparan; sulfate; proteoglycans; during

F. Knopf and M. Brand focus on the bone regeneration and glucocorticoid-induced osteoporosis (GIO) using zebrafish as a model. Their goals are to investigate the FGF (fibroblast growth factor) signaling pathway and the interaction of FGF with heparan sulfate proteoglycans (HSPG), and to establish FGF morphogenetic gradients, because of their importance for normal and osteoporotic bone regeneration. These results provide insights into the interaction of HSPG and FGFs during adult bone regeneration after trauma and its modulation by glucocorticoids.

F. Knopf和M. Brand以斑马鱼为模型研究了骨再生和糖皮质激素诱导的骨质疏松症（GIO）。他们的目标是研究FGF（成纤维细胞生长因子）信号通路以及FGF与硫酸肝素蛋白聚糖（HSPG）的相互作用，并建立FGF的形态发生梯度，因为它们对正常和骨质疏松性骨再生很重要。这些结果为创伤后成人骨再生过程中HSPG和FGFs的相互作用以及糖皮质激素对其的调节提供了见解。