GSC 218: Konstanz Research School Chemical Biology (KoRS-CB)

GSC 218：康斯坦茨研究学院化学生物学（KoRS-CB）

• 批准号: 39072414
• 金额: --
• 依托单位: Universität Konstanz
• 依托单位国家: 德国
• 项目类别: Graduate Schools
• 财政年份: 2007
• 资助国家: 德国
• 起止时间: 2006-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/39072414?language=en
• 关键词: GSC; 218; Konstanz; Research; Chemical

After the determination of the human genome sequence, the elucidation of the intricate network of molecular interactions that govern physiological processes at the cellular and systemic level has become a major focus of investigation both for basic and applied research. A potential key to understanding the mechanisms that determine and control biological processes is the comprehensive characterisation of individual proteins and their interaction with small and macromolecular ligands. To accomplish this fascinating and challenging task, the traditional separation of science into different disciplines lost its justification and the respective expertise of the different areas of research merged into synergistic interdisciplinary approaches. Indeed, there is an increasing demand in academia, research institutions and industrial companies for scientists who are trained at the interface of chemistry and biology.

在人类基因组序列确定之后，阐明在细胞和系统水平上控制生理过程的复杂分子相互作用网络已成为基础研究和应用研究的主要焦点。理解决定和控制生物过程的机制的一个潜在关键是对单个蛋白质及其与小分子和大分子配体相互作用的综合表征。为了完成这一迷人而具有挑战性的任务，传统的将科学分为不同学科的做法失去了其合理性，不同研究领域的各自专业知识合并为协同的跨学科方法。事实上，学术界、研究机构和工业公司对在化学和生物学领域接受过培训的科学家的需求越来越大。

项目成果

Structural insights into the potential of 4-fluoroproline to modulate biophysical properties of proteins

• DOI: 10.1039/c2sc20545a
• 发表时间: 2012-01-01
• 期刊: CHEMICAL SCIENCE
• 影响因子: 8.4
• 作者: Holzberger, Bastian;Obeid, Samra;Marx, Andreas
• 通讯作者: Marx, Andreas

Fingerprinting differential active site constraints of ATPases

• DOI: 10.1039/c3sc21916j
• 发表时间: 2013-01-01
• 期刊: CHEMICAL SCIENCE
• 影响因子: 8.4
• 作者: Hacker, Stephan M.;Hardt, Norman;Marx, Andreas
• 通讯作者: Marx, Andreas

Site-directed spin-labeling of nucleotides and the use of in-cell EPR to determine long-range distances in a biologically relevant environment

• DOI: 10.1038/nprot.2012.136
• 发表时间: 2013-01-01
• 期刊: NATURE PROTOCOLS
• 影响因子: 14.8
• 作者: Azarkh, Mykhailo;Singh, Vijay;Drescher, Malte
• 通讯作者: Drescher, Malte

Investigation of mRNA quadruplex formation in Escherichia coli

• DOI: 10.1038/nprot.2009.111
• 发表时间: 2009-11
• 期刊: Nature Protocols
• 影响因子: 14.8
• 作者: Markus Wieland;J. Hartig

Protein phosphatase 1 is essential for Greatwall inactivation at mitotic exit

• DOI: 10.15252/embr.201540876
• 发表时间: 2015-11-01
• 期刊: EMBO REPORTS
• 影响因子: 7.7
• 作者: Heim, Andreas;Konietzny, Anja;Mayer, Thomas U.
• 通讯作者: Mayer, Thomas U.