Patient-specific lung model development, clinical validation and prediction of ventilatory response

该项目的主要思想是考虑到局部（病理）生理现象的患者特异性计算肺模型的发展。临床电阻抗断层扫描（EIT）测量验证将是一个重点，完成后允许应用该模型预测患者特定的通气反应。在这项工作中，该模型将在一项回顾性研究中应用于不同的机械通气方案和临床操作，并为未来针对每个患者进行个性化通气治疗铺平道路。

The main idea of this project is the development of a patient-specific computational lung model taking into consideration local (patho-) physiological phenomena. Validation with clinical electrical impedance tomography (EIT) measurements will be one key focus and upon completion allow application of the model for predicting patient specific ventilatory response. In this work, the model will be applied to different mechanical ventilation protocols and clinical manoeuvres in a retrospective study and pave the way for future use in personalising ventilatory treatment for each patient specifically.