Patient-specific lung model development, clinical validation and prediction of ventilatory response

患者特异性肺模型开发、临床验证和通气反应预测

• 批准号: 391941288
• 负责人: Dr. Tobias Becher
• 金额: --
• 依托单位: Klinik für Anästhesiologie und Operative Intensivmedizin
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/391941288?language=en
• 关键词: Patient; specific; lung; model; development

The main idea of this project is the development of a patient-specific computational lung model taking into consideration local (patho-) physiological phenomena. Validation with clinical electrical impedance tomography (EIT) measurements will be one key focus and upon completion allow application of the model for predicting patient specific ventilatory response. In this work, the model will be applied to different mechanical ventilation protocols and clinical manoeuvres in a retrospective study and pave the way for future use in personalising ventilatory treatment for each patient specifically.

该项目的主要思想是开发一个考虑局部（病理）生理现象的患者特定计算肺模型。临床电阻抗断层扫描（EIT）测量的验证将是一个关键的焦点，并在完成后允许应用模型预测患者的特异性免疫反应。在这项工作中，该模型将在回顾性研究中应用于不同的机械通气方案和临床操作，并为未来用于针对每位患者的个性化辅助治疗铺平道路。