Defining New Building Blocks for the Construction of Artificial Genetic Circuits

通过描述天然遗传开关的组成部分，我们将提供一套定义明确的遗传构建模块，用于构建合理设计的生物电路。构建这种电路的能力将在诸如代谢工程的领域中具有显著的经济效益，以提高从微生物生产天然化合物的效率，并且在生物医学中具有显著的经济效益，以控制治疗化合物的释放。荣誉和博士生参与这个项目将使下一代澳大利亚科学家接触到这一新兴学科。通过国际合作，在高影响力的科学期刊上发表论文，将提高澳大利亚的科学声誉。

By characterising the components of a natural genetic switch, we will make available a set of well defined genetic building blocks for construction of rationally designed biological circuits. The ability to build such circuits would have significant economic benefit in areas such as metabolic engineering, to improve the efficiency of production of natural compounds from micro-organisms, and in biomedicine, for the controlled release of therapeutic compounds. The involvement of Honours and Ph.D students in this project will expose the next generation of Australian scientists to this emerging discipline. International collaboration leading to publications in high impact scientific journals will enhance Australia's scientific reputation.