Signal Transduction and Control of T-cell function by Prolactin
Signal Transduction and Control of T-cell function by Prolactin
批准号:
05453176
负责人:
NAKASHIMA Kunio
金额:
$4.74万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for General Scientific Research (B)
财政年份:
1993
资助国家:
日本
项目状态:
已结题
起止时间:
1993 至 1995
中文摘要
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英文摘要
Prolactin has been demonstrated to induce the expression of the genes encoding cyclin D2 and D3 during promotion of the G1/S transition in rat Nb2 pre-T lymphoma cells. cDNA clones encoding these rat cyclins D2 and D3 were isolated and sequenced. The genes for cyclin E,cdk2, cdk5 and E2F-1 are also expressed synergistically at the same stage, suggesting the presence of a common cellular mechanism to stimulate these genes. It has also been found that, during the same G1/S transition phase, prolactin stimulates TCR-nu gene expression in 4 h and represses TCR-alpha and beta genes in the Nb2 cells. These results suggest that prolactin participates in the regulation of mammalian T-cell differentiation and proliferation.
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Yoshitaka Hosokawa 他: "Synergistic gene expressions of cyclin E, cdk2, cdk5 and E2F during the prolactin-induced G1/S transitlon in rat Nb2 pre-T lymphom2 cells" Biochem. Mol. Biol. International. 37. 393-399 (1995)
Yoshitaka Hosokawa 等人:“大鼠 Nb2 前 T 淋巴瘤细胞中催乳素诱导的 G1/S 转变过程中细胞周期蛋白 E、cdk2、cdk5 和 E2F 的协同基因表达”Biochem International。 (1995)
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Kesami Sakaguchi, Minoru Tanaka, Takeshi Ohkubo, Katsumi Doh-ura, Takahiko Fujikawa, Shu Sudo and Kunio Nakashima: "Induction of brain prolactin receptor long form mRNA expression and maternal behavior in the pup-contacted male rats : Promotion by prolact
Kesami Sakaguchi、Minoru Tanaka、Takeshi Ohkubo、Katsumi Doh-ura、Takahiko Fujikawa、Shu Sudo 和 Kunio Nakashima:“在幼仔接触的雄性大鼠中诱导脑催乳素受体长型 mRNA 表达和母性行为:催乳素的促进
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Yoshitaka Hosokawa, Miao Yang, Satoshi Kaneko, Minoru Tanaka and Kunio Nakashima: "Prolactin induces switching of T-cell receptor gene expression from alpha to nu in rat Nb2 pre-T lymphoma cells." Biochem.Biophys.Res.Commun.(in press). (1996)
Yoshitaka Hosokawa、Miao Yang、Satoshi Kaneko、Minoru Tanaka 和 Kunio Nakashima:“催乳素诱导大鼠 Nb2 前 T 淋巴瘤细胞中 T 细胞受体基因表达从 alpha 转变为 nu。”
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Yoshitaka Hosokawa,他: "Prolactin induces switching of T-cell receptor gene expression from α to γ in rat Nb2 pre-T lymphoma cells" Biochem.Biophys.Res.Commun.(印刷中). (1996)
Yoshitaka Hosokawa 等人:“催乳素诱导大鼠 Nb2 前 T 淋巴瘤细胞中 T 细胞受体基因表达从 α 转变为 γ”Biochem.Biophys.Res.Commun.(出版中)。
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Takashi Fujikawa, Hideaki Soya, Hideo Yoshizato, Kesami Sakaguchi, Katsumi Doh-ura, Minoru Tanaka and Kunio Nakashima: "Restraint stress enhaces the gene expression of prolactin receptor long form at the choroid plexus." Endocrinology. 136(12). 5608-5613
Takashi Fujikawa、Hideaki Soya、Hideo Yoshizato、Kesami Sakaguchi、Katsumi Doh-ura、Minoru Tanaka 和 Kunio Nakashima:“束缚压力增强了脉络丛催乳素受体长型的基因表达。”
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共 14 条
Comparison between A. Baeumler and Thomas Mann related to Fascism
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批准号:20520312
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$0.92万
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财政年份:2008
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负责人:NAKASHIMA Kunio
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依托单位:
Studies on the Gene Expression and Physiological Significance of novel Prolactin-Like Proteins in Bovine Placenta
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批准号:01570128
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.41万
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财政年份:1989
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负责人:NAKASHIMA Kunio
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依托单位: