The in vivo role of RNA-binding proteins in neurogenesis, synapse formation and synaptic plasticity (A15*)

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In this new project, we aim to unravel how RBP-dependent asymmetric mRNA distribution in neuronal stem cells, neuronal progenitors and mature neurons influences neuronal differentiation, maturation and subsequent functional integration into existing neural circuits involving the hippocampus. In goal 1, we will investigate the role of Stau2 (and Pum2) in adult neurogenesis. In goal 2, we will unravel the in vivo role of Stau2 in synaptic plasticity and in learning and memory. Special emphasis will be given to the analysis of asymmetric RNA localization in neuronal stem cells and mature neurons.