The in vivo role of RNA-binding proteins in neurogenesis, synapse formation and synaptic plasticity (A15*)

在这个新的项目中，我们的目标是揭示RBP依赖的不对称mRNA在神经干细胞、神经前体细胞和成熟神经元中的分布如何影响神经元的分化、成熟和随后与涉及海马体的现有神经回路的功能整合。在目标1中，我们将研究Stau2(和Pum2)在成人神经发生中的作用。在目标2中，我们将揭示Stau2在突触可塑性和学习记忆中的活体作用。将特别强调不对称RNA在神经干细胞和成熟神经元中的定位分析。

In this new project, we aim to unravel how RBP-dependent asymmetric mRNA distribution in neuronal stem cells, neuronal progenitors and mature neurons influences neuronal differentiation, maturation and subsequent functional integration into existing neural circuits involving the hippocampus. In goal 1, we will investigate the role of Stau2 (and Pum2) in adult neurogenesis. In goal 2, we will unravel the in vivo role of Stau2 in synaptic plasticity and in learning and memory. Special emphasis will be given to the analysis of asymmetric RNA localization in neuronal stem cells and mature neurons.