Molecular mechanism of pathogenic network for the onset of joint ankylosis with psoriatic dermatitis

银屑病皮炎关节强直发病的致病网络分子机制

• 批准号: 23659198
• 负责人: ONO Masao
• 金额: $ 2.33万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23659198/
• 关键词: 強直症; 皮膚炎; IL-17; 疾患モデル; 治療実験; 抗サイトカイン療法

Ankylosing arthropathy, such as ankylosing spondylitis, psoriatic arthritis, and so forth, are intractable joint diseases with present therapeutic approaches to other arthropathic disorders. To develop a new effective approach to ankylosing arthropathy, it is necessary to clarify an essential pathogenic mechanism of ankylosis and to obtain evidence for efficacy of a new therapeutic approach in an animal disease model. My previous study had characterized a proper mouse model for the study of human ankylosing diseases. The present study using experimental strains of mice with spontaneous onset of ankylosis showed genetic association of the ankylosis onset, pathogenic contribution of testis to male preponderance of this onset, histopathological characteristics of early to late phases after the ankylosis onset, and therapeutic efficacy of anti-IL-17 administration.

强直性关节病，如强直性脊柱炎、银屑病关节炎等，是难治性关节疾病，目前的治疗方法是治疗其他关节病性疾病。为了开发治疗强直性关节病的新的有效方法，有必要阐明强直的基本致病机制，并在动物疾病模型中获得新治疗方法有效性的证据。我之前的研究已经为人类强直性疾病的研究提供了一个合适的小鼠模型。本研究使用自发性强直发作的小鼠实验品系，显示强直发作的遗传相关性、睾丸对男性发病优势的致病贡献、强直发作后早期至晚期的组织病理学特征以及抗IL-17给药的治疗效果。

项目成果

動物モデルの関節強直症に対する抗IL-17抗体投与の抑制効果

抗IL-17抗体给药对动物模型关节强直的抑制作用

• 发表时间: 2011
• 作者: 海老原伸;小野栄夫
• 通讯作者: 小野栄夫

A novel autoantibody against fibronectin leucine-rich transmembrane protein 2 expressed on the endothelial cell surface identified by retroviral vector system in systemic lupus erythematosus.

一种针对纤连蛋白亮氨酸亮氨酸的跨膜蛋白2的新型自身抗体，该蛋白2在全身性红斑狼疮的逆转录病毒载体系统鉴定出的内皮细胞表面上表达。

• DOI: 10.1186/ar3897
• 发表时间: 2012-07-02
• 期刊: Arthritis research & therapy
• 影响因子: 4.9
• 作者: Shirai T;Fujii H;Ono M;Nakamura K;Watanabe R;Tajima Y;Takasawa N;Ishii T;Harigae H
• 通讯作者: Harigae H

Presumptive Role of 129 Strain-Derived Sle16 Locus in Rheumatoid Arthritis in a New Mouse Model With Fcγ Receptor Type IIb-Deficient C57BL/6 Genetic Background

• DOI: 10.1002/art.30485
• 发表时间: 2011-10-01
• 期刊: ARTHRITIS AND RHEUMATISM
• 作者: Sato-Hayashizaki, Aya;Ohtsuji, Mareki;Hirose, Sachiko
• 通讯作者: Hirose, Sachiko

Bach1 is critical for the transformation of mouse embryonic fibroblasts by RasV12 and maintains ERK signaling

• DOI: 10.1038/onc.2012.336
• 发表时间: 2013-07-04
• 期刊: ONCOGENE
• 影响因子: 8
• 作者: Nakanome, A.;Brydun, A.;Igarashi, K.
• 通讯作者: Igarashi, K.

Indispensable roles of OX40L-derived signal and epistatic genetic effect in immune-mediated pathogenesis of spontaneous pulmonary hypertension.

• DOI: 10.1186/1471-2172-12-67
• 发表时间: 2011-12-15
• 期刊: BMC immunology
• 影响因子: 3
• 作者: Rabieyousefi M;Soroosh P;Satoh K;Date F;Ishii N;Yamashita M;Oka M;McMurtry IF;Shimokawa H;Nose M;Sugamura K;Ono M
• 通讯作者: Ono M