Novel angiogenesis inhibitor DBP-maf for cancer therapy
Novel angiogenesis inhibitor DBP-maf for cancer therapy
批准号:
23659611
负责人:
MATSUURA Nariaki
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
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英文摘要
DBP-maf (Vitamin D binding protein-macrophage activating factor) showed inhibitory activity for angiogenesis through suppressive effect on endothelial proliferation, adhesion activity to extracellular matrix proteins, migration capacity, and tube formation. DBP-maf inhibits markedly angiogenesis by Aorta ring assay, Das assay and Matrigel plague assay. Furthermore DBP-maf has stimulatory effect on macrophage activation. DBP-maf suppresses growth of hepatocellular carcinoma or pancreatic carcinoma cell lines in vivo.
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DOI:
10.1371/journal.pone.0057927
发表时间:
2013
期刊:
PloS one
影响因子:
3.7
作者:
[Mori S, Tran V, Nishikawa K, Kaneda T, Hamada Y, Kawaguchi N, Fujita M, Saegusa J, Takada YK, Matsuura N, Zhao M, Takada Y]
通讯作者:
Takada Y
DOI:
10.1093/cvr/cvt088
发表时间:
2013-07-01
期刊:
CARDIOVASCULAR RESEARCH
影响因子:
10.8
作者:
[Uchinaka, Ayako, Kawaguchi, Naomasa, Matsuura, Nariaki]
通讯作者:
Matsuura, Nariaki
大腸癌リンパ節転移におけるOSNA法を用いた新たな分子生物学的検査法の意義
OSNA方法新的分子生物学检测结直肠癌淋巴结转移的意义
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[宮崎進, 山本浩文, 賀川義規, 鈴木陽三, 竹政伊知朗, 水島恒和, 池田正孝, 関本貢嗣, 松浦成昭, 土岐祐一郎, 森正樹]
通讯作者:
森正樹
Aberrant expression of disintegrin-metalloprotease proteins in the formation and progression of uterine cervical cancer
解整合素金属蛋白酶蛋白的异常表达在宫颈癌的形成和进展中
DOI:
--
发表时间:
2011
期刊:
Pathobiol
影响因子:
--
作者:
[M. Shaker, Y. Yokoyama, S. Mori, M. Tsujimoto, N. Kawaguchi, T. Kiyono, T. Nakano, N. Matsuura]
通讯作者:
N. Matsuura
DOI:
10.1016/j.jss.2010.07.057
发表时间:
2012-01-01
期刊:
JOURNAL OF SURGICAL RESEARCH
影响因子:
2.2
作者:
[Nonaka, Koichi, Onizuka, Shinya, Fujioka, Hikaru]
通讯作者:
Fujioka, Hikaru
Regulation of adhesion molecule integrins by membrane-bound proteinase ADAM
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批准号:16390117
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.54万
-
财政年份:2004
-
负责人:MATSUURA Nariaki
-
依托单位:
Application of integrin α4β1 for diagnosis and therapy of bone metastasis
-
批准号:10670158
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.43万
-
财政年份:1998
-
负责人:MATSUURA Nariaki
-
依托单位:
Study on the role of integrin alpha4beta1 in bone metastasis
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批准号:06670239
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.28万
-
财政年份:1994
-
负责人:MATSUURA Nariaki
-
依托单位:
海外基金