The production of the pigs with an artificial gene (a functional domain-polymeriged nucleotide based on optimal codonusage)

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T o establish transgenic pigs with multiple human genes, the hybrid gene containing the function domains of each molecule were produced and the pigs with the gene was then tried to produce by intracytoplasmic sperm injection(ICSI) methods. At first, the transgenic mouse with the hybrid genes were successfully produced and analyzed. Concerning the pig project, the condition of the oocyte with each gene was studied under the microscope. The condition of the segmentation was no problem, however the pigs with genes were not born in this period.