Development of liver tissue regeneration therapy using a novel low-power extracorporeal shock wave for treatment of liver cirrhosis

目前，基本上还没有治疗肝硬化的灵丹妙药。预防并发症并帮助肝硬化肝脏的功能非常重要。强烈需要开发高效且微创的新疗法。已经报道了通过低功率体外冲击波照射缺血组织来抑制血管生成活性和心肌重塑。我们阐明了低功率体外冲击波对肝硬化的作用。在这项研究中，我们使用大鼠的动物模型评估了肝功能、细胞再生、纤维化程度、血管生成活性和不良事件。虽然低功率体外冲击波照射是安全进行的，但还需要进一步考虑最佳条件和生物学机制。

There is no silver bullet of the treatment for liver cirrhosis currently and essentially. It is important to prevent the complications and help the function of the cirrhotic liver. Development of new treatments highly effective and minimally invasive is strongly desired. Angiogenic activity and inhibition of myocardial remodeling have been reported by irradiation of the low power extracorporeal shock wave to the ischemic tissue. We elucidate the effect of the low power extracorporeal shock wave for the liver cirrhosis. In this study, we evaluate the liver function, cell regeneration, degree of fibrosis, angiogenic activity and adverse events in the animal model using rat. Although the irradiation of the low power extracorporeal shock wave were performed safely, it is necessary to consider the optimum condition and the biological mechanism further more.