Development of liver tissue regeneration therapy using a novel low-power extracorporeal shock wave for treatment of liver cirrhosis

开发利用新型低功率体外冲击波治疗肝硬化的肝组织再生疗法

• 批准号: 23659633
• 负责人: MIYATA Go
• 金额: $ 2.41万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23659633/
• 关键词: 肝; 衝撃波; 肝硬変; 体外衝撃波; 肝再生; 血管新生

There is no silver bullet of the treatment for liver cirrhosis currently and essentially. It is important to prevent the complications and help the function of the cirrhotic liver. Development of new treatments highly effective and minimally invasive is strongly desired. Angiogenic activity and inhibition of myocardial remodeling have been reported by irradiation of the low power extracorporeal shock wave to the ischemic tissue. We elucidate the effect of the low power extracorporeal shock wave for the liver cirrhosis. In this study, we evaluate the liver function, cell regeneration, degree of fibrosis, angiogenic activity and adverse events in the animal model using rat. Although the irradiation of the low power extracorporeal shock wave were performed safely, it is necessary to consider the optimum condition and the biological mechanism further more.

肝硬化的治疗目前基本上没有银。预防并发症的发生，恢复肝病的功能是非常重要的。强烈期望开发高效且微创的新治疗方法。低功率体外冲击波对缺血组织的照射具有血管生成活性和抑制心肌重塑的作用。目的探讨低能量体外冲击波治疗肝硬化的疗效。在这项研究中，我们评估了使用大鼠的动物模型的肝功能，细胞再生，纤维化程度，血管生成活性和不良事件。虽然低功率体外冲击波的照射是安全的，但其最佳照射条件和生物学机制仍需进一步研究。

项目成果

低出力衝撃波の肝に及ぼす影響についての研究

低功率冲击波对肝脏影响的研究

• 发表时间: 2012
• 作者: 山田誠人;中野徹;宮田剛
• 通讯作者: 宮田剛

低出力衝撃波の肝に及ぼす 影響についての研究

低功率冲击波对肝脏的影响

• 作者: 柳衛宏宣;高橋浩之;小暮公孝;山田誠人
• 通讯作者: 山田誠人

Experimental application of low power shock wave for the treatment of liver cirrhosis

低功率冲击波治疗肝硬化的实验应用

• 发表时间: 2011
• 作者: Nakano T;Yamada S. Miyata;G
• 通讯作者: G