Development of liver tissue regeneration therapy using a novel low-power extracorporeal shock wave for treatment of liver cirrhosis

肝硬化的治疗目前基本上没有银。预防并发症的发生，恢复肝病的功能是非常重要的。强烈期望开发高效且微创的新治疗方法。低功率体外冲击波对缺血组织的照射具有血管生成活性和抑制心肌重塑的作用。目的探讨低能量体外冲击波治疗肝硬化的疗效。在这项研究中，我们评估了使用大鼠的动物模型的肝功能，细胞再生，纤维化程度，血管生成活性和不良事件。虽然低功率体外冲击波的照射是安全的，但其最佳照射条件和生物学机制仍需进一步研究。

There is no silver bullet of the treatment for liver cirrhosis currently and essentially. It is important to prevent the complications and help the function of the cirrhotic liver. Development of new treatments highly effective and minimally invasive is strongly desired. Angiogenic activity and inhibition of myocardial remodeling have been reported by irradiation of the low power extracorporeal shock wave to the ischemic tissue. We elucidate the effect of the low power extracorporeal shock wave for the liver cirrhosis. In this study, we evaluate the liver function, cell regeneration, degree of fibrosis, angiogenic activity and adverse events in the animal model using rat. Although the irradiation of the low power extracorporeal shock wave were performed safely, it is necessary to consider the optimum condition and the biological mechanism further more.