Free radical generation following shock liver

本研究应用微透析技术，观察了休克后肝组织中羟自由基（OH）和一氧化氮（NO）的生成情况。在体肝组织中OH的产生在休克后1和7小时增加。在休克前给予氨基胍可使休克时肝组织NO的生成几乎在各时相都受到抑制，OH产物减少，提示在休克肝中调控iNOS，不仅可以控制NO的生成，而且可以控制OH的生成。我们可以在急诊和重症监护中减轻休克后的肝损伤。

The aim of this study was to investigate the generation ofhydroxylradical(OH) and nitric oxide (NO) in the hepatic tissue in vivo after in shock liver by using microdialysis technique. The generation of OH in the hepatic tissue in vivo increased at 1 and 7 hour after shock. The administration of aminoguanidine before shock caused the inhibition of NO and the reduction of OH products in the hepatic tissue at almost all phases.Thease results suggest that if we can regulate iNOS in shock liver, we can control not only the production of NO generation in the liver, but also the production of the hydroxyl radical. We may relieve a liver damage after the shock in the emergency and intensive care.