Novel luminophors with aggregation induced emission properties for protein recognition (A10)

具有聚集诱导发射特性的新型发光体，用于蛋白质识别 (A10)

• 批准号: 394580504
• 金额: --
• 依托单位: Organische Chemie - AG Voskuhl
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/394580504?language=en
• 关键词: Novel; luminophors; aggregation; induced; emission

Project A10 deals with the synthesis, characterisation and application of novel luminophores with aggregation-induced emission for the recognition of proteins. To this end novel artificial amino-acids will be synthesized and used in a peptide library. Upon binding to a protein a fluorescence signal is expected due to a restriction of intramolecular rotation of the luminophores. This approach represents a completely new tool for the identification of protein ligands. Furthermore we aim for the synthesis of multivalent platforms with AIE properties in collaboration with groups from the CRC 1093 for the recognition of protein surfaces, pores and binding pockets.

项目A10涉及用于蛋白质识别的具有聚集诱导发射的新型发光体的合成、表征和应用。为此，将合成新的人工氨基酸，并将其用于多肽文库。当与蛋白质结合时，由于发光团分子内旋转的限制，预期会有荧光信号。这种方法代表了一种识别蛋白质配体的全新工具。此外，我们的目标是与CRC1093的小组合作，合成具有AIE性质的多价平台，用于识别蛋白质表面、孔和结合口袋。